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Radiation induced sterilization of polymeric materials for medical implants—I. Radiation-induced damage in irradiated polymethylmethacrylate

Identifieur interne : 006538 ( Main/Exploration ); précédent : 006537; suivant : 006539

Radiation induced sterilization of polymeric materials for medical implants—I. Radiation-induced damage in irradiated polymethylmethacrylate

Auteurs : Z. Livne [États-Unis] ; Y. Haruvy [États-Unis] ; N. Lao [États-Unis] ; M. Ryeom [États-Unis] ; E. P. Mueller [États-Unis]

Source :

Abstract

Polymeric materials in medical implants must tolerate the sterilization step. Irradiation is the preferred sterilization method, except for possible long-term degradation processes which may proceed after the implantation and endanger the reliable functioning of polymeric materials in medical devices. The scope and complexity of the long-term degradation problem are demonstrated, using irradiated polymethylmethacrylate (PMMA) samples of various compositions. Further, the variance of damage routes and the consequent failure modes are discussed. The conclusional rationale is that forecasting of the radiation-induced in vivo long-term degradation is unrealistic. An alternative route to solve this problem is suggested, established on the total elimination of the long-term degradation processes.


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DOI: 10.1016/1359-0197(91)90084-F


Affiliations:


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