DanceTherParkinsonV1, Main, Exploration, bibRecord, 000055

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

Identifieur interne : 000055 ( Main/Exploration ); précédent : 000054; suivant : 000056

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

Auteurs : David P. Breen ; Romina Vuono ; Upekshani Nawarathna ; Kate Fisher ; John M. Shneerson ; Akhilesh B. Reddy ; Roger A. Barker

Source :

JAMA neurology [ 2168-6149 ] ; 2014.

RBID : PMC:4119609

Abstract

IMPORTANCE

Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood.

OBJECTIVE

To define the sleep and circadian phenotype of patients with early-stage Parkinson disease.

DESIGN, SETTING, AND PARTICIPANTS

Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15).

MAIN OUTCOMES AND MEASURES

Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (Bmal1, Per2, and Rev-Erbα).

RESULTS

Subjective sleep complaints were present in almost half of newly diagnosed patients and correlated significantly with poorer quality of life. Patients with Parkinson disease exhibited increased sleep latency (P = .04), reduced sleep efficiency (P = .008), and reduced rapid eye movement sleep (P = .02). In addition, there was a sustained elevation of serum cortisol levels, reduced circulating melatonin levels, and altered Bmal1 expression in patients with Parkinson disease compared with controls.

CONCLUSIONS AND RELEVANCE

Sleep dysfunction seen in early Parkinson disease may reflect a more fundamental pathology in the molecular clock underlying circadian rhythms.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4119609

DOI: 10.1001/jamaneurol.2014.65
PubMed: 24687146
PubMed Central: 4119609

Affiliations:

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<author><name sortKey="Nawarathna, Upekshani" sort="Nawarathna, Upekshani" uniqKey="Nawarathna U" first="Upekshani" last="Nawarathna">Upekshani Nawarathna</name>
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<author><name sortKey="Fisher, Kate" sort="Fisher, Kate" uniqKey="Fisher K" first="Kate" last="Fisher">Kate Fisher</name>
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<author><name sortKey="Shneerson, John M" sort="Shneerson, John M" uniqKey="Shneerson J" first="John M." last="Shneerson">John M. Shneerson</name>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>IMPORTANCE</title>
<p id="P10">Sleep disturbances are recognized as a common nonmotor complaint in Parkinson disease but their etiology is poorly understood.</p>
</sec>
<sec id="S2"><title>OBJECTIVE</title>
<p id="P11">To define the sleep and circadian phenotype of patients with early-stage Parkinson disease.</p>
</sec>
<sec id="S3"><title>DESIGN, SETTING, AND PARTICIPANTS</title>
<p id="P12">Initial assessment of sleep characteristics in a large population-representative incident Parkinson disease cohort (N=239) at the University of Cambridge, England, followed by further comprehensive case-control sleep assessments in a subgroup of these patients (n=30) and matched controls (n=15).</p>
</sec>
<sec id="S4"><title>MAIN OUTCOMES AND MEASURES</title>
<p id="P13">Sleep diagnoses and sleep architecture based on polysomnography studies, actigraphy assessment, and 24-hour analyses of serum cortisol, melatonin, and peripheral clock gene expression (<italic>Bmal1, Per2</italic>
, and <italic>Rev-Erb</italic>
α).</p>
</sec>
<sec id="S5"><title>RESULTS</title>
<p id="P14">Subjective sleep complaints were present in almost half of newly diagnosed patients and correlated significantly with poorer quality of life. Patients with Parkinson disease exhibited increased sleep latency (<italic>P</italic>
 = .04), reduced sleep efficiency (<italic>P</italic>
 = .008), and reduced rapid eye movement sleep (<italic>P</italic>
 = .02). In addition, there was a sustained elevation of serum cortisol levels, reduced circulating melatonin levels, and altered <italic>Bmal1</italic>
 expression in patients with Parkinson disease compared with controls.</p>
</sec>
<sec id="S6"><title>CONCLUSIONS AND RELEVANCE</title>
<p id="P15">Sleep dysfunction seen in early Parkinson disease may reflect a more fundamental pathology in the molecular clock underlying circadian rhythms.</p>
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<name sortKey="Breen, David P" sort="Breen, David P" uniqKey="Breen D" first="David P." last="Breen">David P. Breen</name>
<name sortKey="Fisher, Kate" sort="Fisher, Kate" uniqKey="Fisher K" first="Kate" last="Fisher">Kate Fisher</name>
<name sortKey="Nawarathna, Upekshani" sort="Nawarathna, Upekshani" uniqKey="Nawarathna U" first="Upekshani" last="Nawarathna">Upekshani Nawarathna</name>
<name sortKey="Reddy, Akhilesh B" sort="Reddy, Akhilesh B" uniqKey="Reddy A" first="Akhilesh B." last="Reddy">Akhilesh B. Reddy</name>
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<name sortKey="Vuono, Romina" sort="Vuono, Romina" uniqKey="Vuono R" first="Romina" last="Vuono">Romina Vuono</name>
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Danse-thérapie et Parkinson

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

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Abstract

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