Serveur d'exploration sur Heinrich Schütz

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus

Identifieur interne : 001724 ( Main/Exploration ); précédent : 001723; suivant : 001725

Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus

Auteurs : F. Anders [Allemagne]

Source :

RBID : ISTEX:DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5

Abstract

Summary: The genetic information for neoplastic transformation is inherited as a normal part of the genome in all individuals of Xiphophorus. Neoplasia, however, was found only in hybrids between members of different populations and local races. It can be classified in (a) a large group that is triggered by mutagens, (b) a large group triggered by promoters, (c) a small group that develops “spontaneously”, and (d) a small group that is inherited according to Mendelian Laws. The process leading to susceptibility for neoplasia is represented by the disintegration of coadapted gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene-systems. Environmental mutagens and promoters (i.e. carcinogens) may complete disintegration and thus may trigger neoplasia. The phenomenon of introducing susceptibility to neoplasia by means of hybridization has been observed in a large variety of plants and animals (Table 2). While we have no data on the relation between hybridization and cancer in human beings comparable to those in plants and animals, we put the question whether the many facts on tumor incidence in humans, that do not agree with the concept of the primacy of environmental factors in carcinogenesis may be explained by interpopulational and interracial hybridization in preceding generations. Based on our studies on Xiphophorus we suppose that environmental factors represent only the peak of an iceberg in the multistep process of the causation of neoplasia. The most important steps leading to neoplasia, i.e. those that bring about susceptibility, are supposed to be hidden in our ancestry.


Url:
DOI: 10.1007/BF02310969


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="de">Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus</title>
<author>
<name sortKey="Anders, F" sort="Anders, F" uniqKey="Anders F" first="F." last="Anders">F. Anders</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5</idno>
<date when="1981" year="1981">1981</date>
<idno type="doi">10.1007/BF02310969</idno>
<idno type="url">https://api.istex.fr/document/DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000621</idno>
<idno type="wicri:Area/Main/Curation">000620</idno>
<idno type="wicri:Area/Main/Exploration">001724</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="de">Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus</title>
<author>
<name sortKey="Anders, F" sort="Anders, F" uniqKey="Anders F" first="F." last="Anders">F. Anders</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Genetisches Institut der Justus-Liebig-Universität Gießen</wicri:regionArea>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Klinische Wochenschrift</title>
<title level="j" type="abbrev">Klin Wochenschr</title>
<idno type="ISSN">0023-2173</idno>
<idno type="eISSN">1432-1440</idno>
<imprint>
<publisher>Springer-Verlag</publisher>
<pubPlace>Berlin/Heidelberg</pubPlace>
<date type="published" when="1981-09-01">1981-09-01</date>
<biblScope unit="volume">59</biblScope>
<biblScope unit="issue">17</biblScope>
<biblScope unit="page" from="943">943</biblScope>
<biblScope unit="page" to="956">956</biblScope>
</imprint>
<idno type="ISSN">0023-2173</idno>
</series>
<idno type="istex">DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5</idno>
<idno type="DOI">10.1007/BF02310969</idno>
<idno type="ArticleID">Art4</idno>
<idno type="ArticleID">BF02310969</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0023-2173</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass></textClass>
<langUsage>
<language ident="de">de</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Summary: The genetic information for neoplastic transformation is inherited as a normal part of the genome in all individuals of Xiphophorus. Neoplasia, however, was found only in hybrids between members of different populations and local races. It can be classified in (a) a large group that is triggered by mutagens, (b) a large group triggered by promoters, (c) a small group that develops “spontaneously”, and (d) a small group that is inherited according to Mendelian Laws. The process leading to susceptibility for neoplasia is represented by the disintegration of coadapted gene systems that normally protect the fish from neoplasia. Hybridization is the most effective process that leads to disintegration of the protection gene-systems. Environmental mutagens and promoters (i.e. carcinogens) may complete disintegration and thus may trigger neoplasia. The phenomenon of introducing susceptibility to neoplasia by means of hybridization has been observed in a large variety of plants and animals (Table 2). While we have no data on the relation between hybridization and cancer in human beings comparable to those in plants and animals, we put the question whether the many facts on tumor incidence in humans, that do not agree with the concept of the primacy of environmental factors in carcinogenesis may be explained by interpopulational and interracial hybridization in preceding generations. Based on our studies on Xiphophorus we suppose that environmental factors represent only the peak of an iceberg in the multistep process of the causation of neoplasia. The most important steps leading to neoplasia, i.e. those that bring about susceptibility, are supposed to be hidden in our ancestry.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
</country>
</list>
<tree>
<country name="Allemagne">
<noRegion>
<name sortKey="Anders, F" sort="Anders, F" uniqKey="Anders F" first="F." last="Anders">F. Anders</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/corpus/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001724 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Musique
   |area=    SchutzV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:DC1DF82C7C359B35FFCBBE548E888C0376EBEDA5
   |texte=   Erb- und Umweltfaktoren im Ursachengefüge des neoplastischen Wachstums nach Studien an Xiphophorus
}}

Wicri

This area was generated with Dilib version V0.6.20.
Data generation: Sun Apr 10 01:23:10 2016. Site generation: Fri Aug 18 21:45:27 2017