Serveur d'exploration sur Heinrich Schütz

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Cardiac adenosine production is linked to myocardial pO2

Identifieur interne : 001151 ( Main/Exploration ); précédent : 001150; suivant : 001152

Cardiac adenosine production is linked to myocardial pO2

Auteurs : Andreas Deussen [Allemagne] ; Jürgen Schrader [Allemagne]

Source :

RBID : ISTEX:1A59AEFBE0D604C7A9151F88BC3D83737912B436

Abstract

Experiments were performed on isolated perfused guinea-pig hearts (n=45) to further evaluate the stimulus that triggers cardiac adenosine production. Stimulation of hearts with isoproterenol (4 nm, 20 min) enhanced left ventricular dP dtmax, heart rate and myocardial oxygen consumption within 1 min to new steady state values, whereas coronary venous adenosine concentration only transiently increased reaching its maximum between 1 and 3 min of stimulation. Rate of accumulation of S-adenosylhomocysteine (SAH), a measure of the free cytosolic adenosine concentration, was steepest immediately following onset of stimulation and then progressively declined. Similar to adenosine, changes in coronary venous pO2 were phasic and adenosine release and pO2 closely correlated. Norepinephrine (20 nm) which increased myocardial oxygen consumption to a comparable extent as isoproterenol (4 nm) further decreased coronary venous pO2 and increased coronary venous adenosine. When myocardial oxygen supply was systematically varied by changing coronary perfusion pressure from 60 to 90 and 35 cmH2O, respectively, the adenosine release during isoproterenol (2nm) was markedly enhanced at 35 cmH2O but blunted at 90 cmH2O. Similarly SAH accumulation was greatest at 35 cmH2O and smallest at 90 cmH2O. It is concluded that changing myocardial oxygen consumption is not a sufficient cause to enhance adenosine formation. Myocardial oxygenation as reflected by changes in coronary venous pO2 closely correlates with changes in free cardiac adenosine as evidenced by two independent indices: tissues SAH and coronary venous adenosine concentration. The stimulus triggering cardiac adenosine formation is most likely the imbalance of oxygen supply and oxygen demand.


Url:
DOI: 10.1016/0022-2828(91)90173-J


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title>Cardiac adenosine production is linked to myocardial pO2</title>
<author>
<name sortKey="Deussen, Andreas" sort="Deussen, Andreas" uniqKey="Deussen A" first="Andreas" last="Deussen">Andreas Deussen</name>
</author>
<author>
<name sortKey="Schrader, Jurgen" sort="Schrader, Jurgen" uniqKey="Schrader J" first="Jürgen" last="Schrader">Jürgen Schrader</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:1A59AEFBE0D604C7A9151F88BC3D83737912B436</idno>
<date when="1991" year="1991">1991</date>
<idno type="doi">10.1016/0022-2828(91)90173-J</idno>
<idno type="url">https://api.istex.fr/document/1A59AEFBE0D604C7A9151F88BC3D83737912B436/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000276</idno>
<idno type="wicri:Area/Main/Curation">000276</idno>
<idno type="wicri:Area/Main/Exploration">001151</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a">Cardiac adenosine production is linked to myocardial pO2</title>
<author>
<name sortKey="Deussen, Andreas" sort="Deussen, Andreas" uniqKey="Deussen A" first="Andreas" last="Deussen">Andreas Deussen</name>
<affiliation wicri:level="1">
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Zentrum für Physiologie der Heinrich-Heine-Universität, Moorenstr. 5, 4000 Düsseldorf</wicri:regionArea>
<wicri:noRegion>4000 Düsseldorf</wicri:noRegion>
<wicri:noRegion>4000 Düsseldorf</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Schrader, Jurgen" sort="Schrader, Jurgen" uniqKey="Schrader J" first="Jürgen" last="Schrader">Jürgen Schrader</name>
<affiliation wicri:level="1">
<country xml:lang="fr" wicri:curation="lc">Allemagne</country>
<wicri:regionArea>Zentrum für Physiologie der Heinrich-Heine-Universität, Moorenstr. 5, 4000 Düsseldorf</wicri:regionArea>
<wicri:noRegion>4000 Düsseldorf</wicri:noRegion>
<wicri:noRegion>4000 Düsseldorf</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Journal of Molecular and Cellular Cardiology</title>
<title level="j" type="abbrev">YJMCC</title>
<idno type="ISSN">0022-2828</idno>
<imprint>
<publisher>ELSEVIER</publisher>
<date type="published" when="1990">1990</date>
<biblScope unit="volume">23</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="495">495</biblScope>
<biblScope unit="page" to="504">504</biblScope>
</imprint>
<idno type="ISSN">0022-2828</idno>
</series>
<idno type="istex">1A59AEFBE0D604C7A9151F88BC3D83737912B436</idno>
<idno type="DOI">10.1016/0022-2828(91)90173-J</idno>
<idno type="PII">0022-2828(91)90173-J</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0022-2828</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass></textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Experiments were performed on isolated perfused guinea-pig hearts (n=45) to further evaluate the stimulus that triggers cardiac adenosine production. Stimulation of hearts with isoproterenol (4 nm, 20 min) enhanced left ventricular dP dtmax, heart rate and myocardial oxygen consumption within 1 min to new steady state values, whereas coronary venous adenosine concentration only transiently increased reaching its maximum between 1 and 3 min of stimulation. Rate of accumulation of S-adenosylhomocysteine (SAH), a measure of the free cytosolic adenosine concentration, was steepest immediately following onset of stimulation and then progressively declined. Similar to adenosine, changes in coronary venous pO2 were phasic and adenosine release and pO2 closely correlated. Norepinephrine (20 nm) which increased myocardial oxygen consumption to a comparable extent as isoproterenol (4 nm) further decreased coronary venous pO2 and increased coronary venous adenosine. When myocardial oxygen supply was systematically varied by changing coronary perfusion pressure from 60 to 90 and 35 cmH2O, respectively, the adenosine release during isoproterenol (2nm) was markedly enhanced at 35 cmH2O but blunted at 90 cmH2O. Similarly SAH accumulation was greatest at 35 cmH2O and smallest at 90 cmH2O. It is concluded that changing myocardial oxygen consumption is not a sufficient cause to enhance adenosine formation. Myocardial oxygenation as reflected by changes in coronary venous pO2 closely correlates with changes in free cardiac adenosine as evidenced by two independent indices: tissues SAH and coronary venous adenosine concentration. The stimulus triggering cardiac adenosine formation is most likely the imbalance of oxygen supply and oxygen demand.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
</country>
</list>
<tree>
<country name="Allemagne">
<noRegion>
<name sortKey="Deussen, Andreas" sort="Deussen, Andreas" uniqKey="Deussen A" first="Andreas" last="Deussen">Andreas Deussen</name>
</noRegion>
<name sortKey="Schrader, Jurgen" sort="Schrader, Jurgen" uniqKey="Schrader J" first="Jürgen" last="Schrader">Jürgen Schrader</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/corpus/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001151 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Musique
   |area=    SchutzV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:1A59AEFBE0D604C7A9151F88BC3D83737912B436
   |texte=   Cardiac adenosine production is linked to myocardial pO2
}}

Wicri

This area was generated with Dilib version V0.6.20.
Data generation: Sun Apr 10 01:23:10 2016. Site generation: Fri Aug 18 21:45:27 2017