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1α,25‐Dihydroxyvitamin D3 receptor as a mediator of transrepression of retinoid signaling

Identifieur interne : 000D78 ( Main/Exploration ); précédent : 000D77; suivant : 000D79

1α,25‐Dihydroxyvitamin D3 receptor as a mediator of transrepression of retinoid signaling

Auteurs : Patsie Polly [Australie, Allemagne] ; Carsten Carlberg [Allemagne] ; John A. Eisman [Australie] ; Nigel A. Morrison [Australie]

Source :

RBID : ISTEX:564510FE8082C4B03DB5B59FB3FED36EE2947C6B

Mots-clés :

Abstract

The receptors for retinoic acid (RA) and for 1α,25‐dihydroxyvitamin D3 (VD), RAR, RXR, and VDR are ligand‐inducible members of the nuclear receptor superfamily. These receptors mediate their regulatory effects by binding as dimeric complexes to response elements located in regulatory regions of hormone target genes. Sequence scanning of the tumor necrosis factor‐α type I receptor (TNFαRI) gene identified a 3′ enhancer region composed of two directly repeated hexameric core motifs spaced by 2 nucleotides (DR2). On this novel DR2‐type sequence, but not on a DR5‐type RA response element, VD was shown to act through its receptor, the vitamin D receptor (VDR), as a repressor of retinoid signalling. The repression appears to be mediated by competitive protein–protein interactions between VDR, RAR, RXR, and possibly their cofactors. This VDR‐mediated transrepression of retinoid signaling suggests a novel mechanism for the complex regulatory interaction between retinoids and VD. J. Cell. Biochem. 67:287–296, 1997. © 1997 Wiley‐Liss, Inc.


Url:
DOI: 10.1002/(SICI)1097-4644(19971201)67:3<287::AID-JCB1>3.0.CO;2-S


Affiliations:


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