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Structural and Functional Characterization of the Rat Neurotrophin-4 Gene

Identifieur interne : 000D48 ( Main/Exploration ); précédent : 000D47; suivant : 000D49

Structural and Functional Characterization of the Rat Neurotrophin-4 Gene

Auteurs : Tuija Salin [Suède] ; T Nis Timmusk [Suède] ; Urban Lendahl [Suède] ; Madis Metsis [Suède]

Source :

RBID : ISTEX:07657537AD2B2D5315D6993E60A034EEA7936DAF

Abstract

Neurotrophin-4 (NT-4) is a member of the neurotrophin family of growth factors. To study the molecular mechanisms that govern NT-4 expression, we have cloned and characterized the rat genome region encoding NT-4. The rat NT-4 gene consists of three exons: two 5′-flanking noncoding exons and a coding exon. NT-4 mRNA transcription is controlled by two promoters flanking the noncoding exons. Alternative splicing of the second intron results in a NT-4 mRNA with a different open reading frame, encoding a shorter protein lacking pre-NT-4 sequence. A rat NT-4 gene fragment, containing all exons and introns in addition to 1.4 kb of the upstream genomic sequence, has been introduced into mice. This transgene enables partial recapitulation of the expression pattern of NT-4 mRNA and confers activity-dependent expression of the NT-4 mRNA in muscle.


Url:
DOI: 10.1006/mcne.1997.0625


Affiliations:


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