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SALL3, a New Member of the Human spalt -like Gene Family, Maps to 18q23

Identifieur interne : 000C00 ( Main/Exploration ); précédent : 000B99; suivant : 000C01

SALL3, a New Member of the Human spalt -like Gene Family, Maps to 18q23

Auteurs : Jürgen Kohlhase [Allemagne] ; Susanna Hausmann [Allemagne] ; Goran Stojmenovic [Allemagne] ; Christa Dixkens [Allemagne] ; Karin Bink [Allemagne] ; Walter Schulz-Schaeffer [Allemagne] ; Mariele Altmann [Allemagne] ; Wolfgang Engel [Allemagne]

Source :

RBID : ISTEX:FA99C3ED317497E4954D4B8F5D41B715E69EF98B

Abstract

spalt (sal) of Drosophila melanogaster is an important developmental regulator gene and encodes a zinc finger protein of unusual but characteristic structure. Two human sal-like genes have been isolated so far, SALL1 on chromosome 16q12.1 and SALL2 on chromosome 14q11.1–q12.1. Truncating mutations of SALL1 have been shown to cause Townes–Brocks syndrome and are thought to result in SALL1 haploinsufficiency. Sequence comparison of SALL1 to the related genes Msal in mouse and Xsal-1 in Xenopus laevis suggested that SALL1 was not the human orthologue of Msal and Xsal-1. By database searching and genomic cloning, we isolated an EST and a corresponding human cosmid clone, which contain coding sequence of a human gene highly similar to mouse Msal. This gene, named SALL3, was found to be expressed in different regions of human fetal brain and in different adult human tissues. The chromosomal localization of SALL3 at 18q23 suggests that haploinsufficiency of this gene might contribute to the phenotype of patients with 18q deletion syndrome.


Url:
DOI: 10.1006/geno.1999.6005


Affiliations:


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<div type="abstract" xml:lang="en">spalt (sal) of Drosophila melanogaster is an important developmental regulator gene and encodes a zinc finger protein of unusual but characteristic structure. Two human sal-like genes have been isolated so far, SALL1 on chromosome 16q12.1 and SALL2 on chromosome 14q11.1–q12.1. Truncating mutations of SALL1 have been shown to cause Townes–Brocks syndrome and are thought to result in SALL1 haploinsufficiency. Sequence comparison of SALL1 to the related genes Msal in mouse and Xsal-1 in Xenopus laevis suggested that SALL1 was not the human orthologue of Msal and Xsal-1. By database searching and genomic cloning, we isolated an EST and a corresponding human cosmid clone, which contain coding sequence of a human gene highly similar to mouse Msal. This gene, named SALL3, was found to be expressed in different regions of human fetal brain and in different adult human tissues. The chromosomal localization of SALL3 at 18q23 suggests that haploinsufficiency of this gene might contribute to the phenotype of patients with 18q deletion syndrome.</div>
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