Serveur d'exploration sur Heinrich Schütz

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Cyclin C is a primary 1α,25‐dihydroxyvitamin D3 responding gene

Identifieur interne : 000B40 ( Main/Exploration ); précédent : 000B39; suivant : 000B41

Cyclin C is a primary 1α,25‐dihydroxyvitamin D3 responding gene

Auteurs : Patsie Polly [Allemagne] ; Carina Danielsson [Allemagne, Suède] ; Magdalena Schr Der [Allemagne] ; Carsten Carlberg [Allemagne]

Source :

RBID : ISTEX:2E983EF579E3B8E87B55E1566EDCD5452DD7BBAD

Abstract

1α,25‐dihydroxyvitamin D3 (VD) is a pleiotropic nuclear hormone that also has effects on cell cycle regulation. VD and its synthetic analogues are known inhibitors of cellular growth and inducers of apoptosis, however, the primary mediator genes of these effects largely remain unknown. In order to identify novel targets for VD, that may be involved in the regulation of the cell cycle, a differential display PCR (ddPCR) approach was applied to the MCF‐7 human breast cancer cell line, which provided the gene for cyclin C as an interesting candidate. Quantitative assessment of cyclin C expression showed that the gene was significantly upregulated by VD and its analogues, EB1089 and CB1093 both on the level of mRNA expression and more so on the level of protein expression in MCF‐7 cells. Upregulation of cyclin C protein expression could also be confirmed in MeWo human melanoma and in U937 human promyelocytic leukemia cells. This observation adds a new gene candidate to the list of primary VD responding genes. Cyclin C is not a typical cyclin, as it apparently modulates the activity of the RNA polymerase II complex, which provides fresh insight into the mechanisms of cell cycle and general transcriptional regulation by VD and its analogues. J. Cell. Biochem. 77:75–81, 2000. © 2000 Wiley‐Liss, Inc.


Url:
DOI: 10.1002/(SICI)1097-4644(20000401)77:1<75::AID-JCB8>3.0.CO;2-Q


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Cyclin C is a primary 1α,25‐dihydroxyvitamin D3 responding gene</title>
<author>
<name sortKey="Polly, Patsie" sort="Polly, Patsie" uniqKey="Polly P" first="Patsie" last="Polly">Patsie Polly</name>
</author>
<author>
<name sortKey="Danielsson, Carina" sort="Danielsson, Carina" uniqKey="Danielsson C" first="Carina" last="Danielsson">Carina Danielsson</name>
</author>
<author>
<name sortKey="Schr Der, Magdalena" sort="Schr Der, Magdalena" uniqKey="Schr Der M" first="Magdalena" last="Schr Der">Magdalena Schr Der</name>
</author>
<author>
<name sortKey="Carlberg, Carsten" sort="Carlberg, Carsten" uniqKey="Carlberg C" first="Carsten" last="Carlberg">Carsten Carlberg</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:2E983EF579E3B8E87B55E1566EDCD5452DD7BBAD</idno>
<date when="2000" year="2000">2000</date>
<idno type="doi">10.1002/(SICI)1097-4644(20000401)77:1<75::AID-JCB8>3.0.CO;2-Q</idno>
<idno type="url">https://api.istex.fr/document/2E983EF579E3B8E87B55E1566EDCD5452DD7BBAD/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000A60</idno>
<idno type="wicri:Area/Main/Curation">000A57</idno>
<idno type="wicri:Area/Main/Exploration">000B40</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">Cyclin C is a primary 1α,25‐dihydroxyvitamin D3 responding gene</title>
<author>
<name sortKey="Polly, Patsie" sort="Polly, Patsie" uniqKey="Polly P" first="Patsie" last="Polly">Patsie Polly</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Physiologische Chemie I, Heinrich‐Heine‐Universität, D‐40001 Düsseldorf</wicri:regionArea>
<wicri:noRegion>40001 Düsseldorf</wicri:noRegion>
<wicri:noRegion>D‐40001 Düsseldorf</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Danielsson, Carina" sort="Danielsson, Carina" uniqKey="Danielsson C" first="Carina" last="Danielsson">Carina Danielsson</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Physiologische Chemie I, Heinrich‐Heine‐Universität, D‐40001 Düsseldorf</wicri:regionArea>
<wicri:noRegion>40001 Düsseldorf</wicri:noRegion>
<wicri:noRegion>D‐40001 Düsseldorf</wicri:noRegion>
</affiliation>
<affiliation wicri:level="4">
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Department of Medical Sciences, Section of Dermatology, Uppsala University, S‐75185 Uppsala</wicri:regionArea>
<orgName type="university">Université d'Uppsala</orgName>
<placeName>
<settlement type="city">Uppsala</settlement>
<region nuts="1">Svealand</region>
<region nuts="1">East Middle Sweden</region>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Schr Der, Magdalena" sort="Schr Der, Magdalena" uniqKey="Schr Der M" first="Magdalena" last="Schr Der">Magdalena Schr Der</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Physiologische Chemie I, Heinrich‐Heine‐Universität, D‐40001 Düsseldorf</wicri:regionArea>
<wicri:noRegion>40001 Düsseldorf</wicri:noRegion>
<wicri:noRegion>D‐40001 Düsseldorf</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Carlberg, Carsten" sort="Carlberg, Carsten" uniqKey="Carlberg C" first="Carsten" last="Carlberg">Carsten Carlberg</name>
<affiliation wicri:level="1">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institut für Physiologische Chemie I, Heinrich‐Heine‐Universität, D‐40001 Düsseldorf</wicri:regionArea>
<wicri:noRegion>40001 Düsseldorf</wicri:noRegion>
<wicri:noRegion>D‐40001 Düsseldorf</wicri:noRegion>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Journal of Cellular Biochemistry</title>
<title level="j" type="abbrev">J. Cell. Biochem.</title>
<idno type="ISSN">0730-2312</idno>
<idno type="eISSN">1097-4644</idno>
<imprint>
<publisher>John Wiley & Sons, Inc.</publisher>
<pubPlace>New York</pubPlace>
<date type="published" when="2000-04-01">2000-04-01</date>
<biblScope unit="volume">77</biblScope>
<biblScope unit="issue">1</biblScope>
<biblScope unit="page" from="75">75</biblScope>
<biblScope unit="page" to="81">81</biblScope>
</imprint>
<idno type="ISSN">0730-2312</idno>
</series>
<idno type="istex">2E983EF579E3B8E87B55E1566EDCD5452DD7BBAD</idno>
<idno type="DOI">10.1002/(SICI)1097-4644(20000401)77:1<75::AID-JCB8>3.0.CO;2-Q</idno>
<idno type="ArticleID">JCB8</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0730-2312</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass></textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">1α,25‐dihydroxyvitamin D3 (VD) is a pleiotropic nuclear hormone that also has effects on cell cycle regulation. VD and its synthetic analogues are known inhibitors of cellular growth and inducers of apoptosis, however, the primary mediator genes of these effects largely remain unknown. In order to identify novel targets for VD, that may be involved in the regulation of the cell cycle, a differential display PCR (ddPCR) approach was applied to the MCF‐7 human breast cancer cell line, which provided the gene for cyclin C as an interesting candidate. Quantitative assessment of cyclin C expression showed that the gene was significantly upregulated by VD and its analogues, EB1089 and CB1093 both on the level of mRNA expression and more so on the level of protein expression in MCF‐7 cells. Upregulation of cyclin C protein expression could also be confirmed in MeWo human melanoma and in U937 human promyelocytic leukemia cells. This observation adds a new gene candidate to the list of primary VD responding genes. Cyclin C is not a typical cyclin, as it apparently modulates the activity of the RNA polymerase II complex, which provides fresh insight into the mechanisms of cell cycle and general transcriptional regulation by VD and its analogues. J. Cell. Biochem. 77:75–81, 2000. © 2000 Wiley‐Liss, Inc.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
<li>Suède</li>
</country>
<region>
<li>East Middle Sweden</li>
<li>Svealand</li>
</region>
<settlement>
<li>Uppsala</li>
</settlement>
<orgName>
<li>Université d'Uppsala</li>
</orgName>
</list>
<tree>
<country name="Allemagne">
<noRegion>
<name sortKey="Polly, Patsie" sort="Polly, Patsie" uniqKey="Polly P" first="Patsie" last="Polly">Patsie Polly</name>
</noRegion>
<name sortKey="Carlberg, Carsten" sort="Carlberg, Carsten" uniqKey="Carlberg C" first="Carsten" last="Carlberg">Carsten Carlberg</name>
<name sortKey="Danielsson, Carina" sort="Danielsson, Carina" uniqKey="Danielsson C" first="Carina" last="Danielsson">Carina Danielsson</name>
<name sortKey="Schr Der, Magdalena" sort="Schr Der, Magdalena" uniqKey="Schr Der M" first="Magdalena" last="Schr Der">Magdalena Schr Der</name>
</country>
<country name="Suède">
<region name="Svealand">
<name sortKey="Danielsson, Carina" sort="Danielsson, Carina" uniqKey="Danielsson C" first="Carina" last="Danielsson">Carina Danielsson</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/corpus/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B40 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Musique
   |area=    SchutzV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:2E983EF579E3B8E87B55E1566EDCD5452DD7BBAD
   |texte=   Cyclin C is a primary 1α,25‐dihydroxyvitamin D3 responding gene
}}

Wicri

This area was generated with Dilib version V0.6.20.
Data generation: Sun Apr 10 01:23:10 2016. Site generation: Fri Aug 18 21:45:27 2017