Serveur d'exploration sur Heinrich Schütz

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

CHRONIC ALCOHOLISM CAUSES DELETERIOUS CONDITIONING OF INNATE IMMUNITY

Identifieur interne : 000858 ( Main/Exploration ); précédent : 000857; suivant : 000859

CHRONIC ALCOHOLISM CAUSES DELETERIOUS CONDITIONING OF INNATE IMMUNITY

Auteurs : Johannes Frank [Allemagne] ; Karin Witte ; Wieland Schro Dl [Allemagne] ; Christine Schu Tt

Source :

RBID : ISTEX:A04415F38A8A223D40D15B4419C207785534070F

Abstract

Aims: To examine the immune consequences of chronic alcoholism in man, in relation to the known association between alcoholism and raised incidence and severity of infections. Methods: In 36 alcoholics without liver disease, at the point of commencing withdrawal from alcohol, the following measures of immune competence were measured: the immunophenotypes of cells, acute phase proteins, the endotoxin-neutralizing capacity (ENC) of the serum, titers of anti-lipopolysaccharide (LPS) antibodies, and ex vivo cytokine inducibility in T cells and monocytes (TNFα, IL1β, IL1RA, IL4, IL6, IL8, IL10 and IL12). The results were compared to those from healthy volunteers (day controls). Measures were repeated after 8–13 days of abstinence. Results: LPS-binding protein (LBP) and soluble CD14 (sCD14) were significantly increased in patients' sera at the outset of withdrawal, whereas reduced titers of anti-LPS IgG (P = 0.012) and a reduced ENC (P = 0.001) were measured. Only ENC rapidly returned to normal values after withdrawal therapy. Cytokine induction with phorbol ester showed no significant alterations in patients' T cells. Patients' monocytes, however, responded to LPS stimulation with enhanced IL1β-, but reduced TNFα- and IL12-production (P = 0.004, P = 0.0042 and P = 0.001, respectively). While IL1- and TNFα-responses normalized after the withdrawal period, impairment of the IL12 response persisted throughout the observation period of 2 weeks. Conclusions: Alcoholism results in a prolonged LPS-mediated hypoinflammatory conditioning of the innate but not the adaptive immune system, which is not reversed immediately after withdrawal. This alcohol-induced status of the immune system predisposes to infections and sepsis by blunting initial response to the pathogens.


Url:
DOI: 10.1093/alcalc/agh083


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI wicri:istexFullTextTei="biblStruct">
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">CHRONIC ALCOHOLISM CAUSES DELETERIOUS CONDITIONING OF INNATE IMMUNITY</title>
<author>
<name sortKey="Frank, Johannes" sort="Frank, Johannes" uniqKey="Frank J" first="Johannes" last="Frank">Johannes Frank</name>
</author>
<author>
<name sortKey="Witte, Karin" sort="Witte, Karin" uniqKey="Witte K" first="Karin" last="Witte">Karin Witte</name>
</author>
<author>
<name sortKey="Schro Dl, Wieland" sort="Schro Dl, Wieland" uniqKey="Schro Dl W" first="Wieland" last="Schro Dl">Wieland Schro Dl</name>
</author>
<author>
<name sortKey="Schu Tt, Christine" sort="Schu Tt, Christine" uniqKey="Schu Tt C" first="Christine" last="Schu Tt">Christine Schu Tt</name>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:A04415F38A8A223D40D15B4419C207785534070F</idno>
<date when="2004" year="2004">2004</date>
<idno type="doi">10.1093/alcalc/agh083</idno>
<idno type="url">https://api.istex.fr/document/A04415F38A8A223D40D15B4419C207785534070F/fulltext/pdf</idno>
<idno type="wicri:Area/Main/Corpus">000215</idno>
<idno type="wicri:Area/Main/Curation">000215</idno>
<idno type="wicri:Area/Main/Exploration">000858</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title level="a" type="main" xml:lang="en">CHRONIC ALCOHOLISM CAUSES DELETERIOUS CONDITIONING OF INNATE IMMUNITY</title>
<author>
<name sortKey="Frank, Johannes" sort="Frank, Johannes" uniqKey="Frank J" first="Johannes" last="Frank">Johannes Frank</name>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
<affiliation wicri:level="1">
<country wicri:rule="url">Allemagne</country>
</affiliation>
</author>
<author>
<name sortKey="Witte, Karin" sort="Witte, Karin" uniqKey="Witte K" first="Karin" last="Witte">Karin Witte</name>
<affiliation>
<wicri:noCountry code="subField">Greifswald and</wicri:noCountry>
</affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Schro Dl, Wieland" sort="Schro Dl, Wieland" uniqKey="Schro Dl W" first="Wieland" last="Schro Dl">Wieland Schro Dl</name>
<affiliation wicri:level="3">
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Bacteriology and Mycology, Faculty of Veterinary Medicine, University of Leipzig, Leipzig</wicri:regionArea>
<placeName>
<region type="land" nuts="1">Saxe (Land)</region>
<region type="district" nuts="2">District de Leipzig</region>
<settlement type="city">Leipzig</settlement>
</placeName>
</affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Schu Tt, Christine" sort="Schu Tt, Christine" uniqKey="Schu Tt C" first="Christine" last="Schu Tt">Christine Schu Tt</name>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
<affiliation>
<wicri:noCountry code="subField"></wicri:noCountry>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series>
<title level="j">Alcohol and Alcoholism</title>
<title level="j" type="abbrev">Alcohol and Alcoholism</title>
<idno type="ISSN">0735-0414</idno>
<idno type="eISSN">1464-3502</idno>
<imprint>
<publisher>Oxford University Press</publisher>
<date type="published" when="2004-NaN">2004-NaN</date>
<biblScope unit="volume">39</biblScope>
<biblScope unit="issue">5</biblScope>
<biblScope unit="page" from="386">386</biblScope>
<biblScope unit="page" to="392">392</biblScope>
</imprint>
<idno type="ISSN">0735-0414</idno>
</series>
<idno type="istex">A04415F38A8A223D40D15B4419C207785534070F</idno>
<idno type="DOI">10.1093/alcalc/agh083</idno>
</biblStruct>
</sourceDesc>
<seriesStmt>
<idno type="ISSN">0735-0414</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass></textClass>
<langUsage>
<language ident="en">en</language>
</langUsage>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Aims: To examine the immune consequences of chronic alcoholism in man, in relation to the known association between alcoholism and raised incidence and severity of infections. Methods: In 36 alcoholics without liver disease, at the point of commencing withdrawal from alcohol, the following measures of immune competence were measured: the immunophenotypes of cells, acute phase proteins, the endotoxin-neutralizing capacity (ENC) of the serum, titers of anti-lipopolysaccharide (LPS) antibodies, and ex vivo cytokine inducibility in T cells and monocytes (TNFα, IL1β, IL1RA, IL4, IL6, IL8, IL10 and IL12). The results were compared to those from healthy volunteers (day controls). Measures were repeated after 8–13 days of abstinence. Results: LPS-binding protein (LBP) and soluble CD14 (sCD14) were significantly increased in patients' sera at the outset of withdrawal, whereas reduced titers of anti-LPS IgG (P = 0.012) and a reduced ENC (P = 0.001) were measured. Only ENC rapidly returned to normal values after withdrawal therapy. Cytokine induction with phorbol ester showed no significant alterations in patients' T cells. Patients' monocytes, however, responded to LPS stimulation with enhanced IL1β-, but reduced TNFα- and IL12-production (P = 0.004, P = 0.0042 and P = 0.001, respectively). While IL1- and TNFα-responses normalized after the withdrawal period, impairment of the IL12 response persisted throughout the observation period of 2 weeks. Conclusions: Alcoholism results in a prolonged LPS-mediated hypoinflammatory conditioning of the innate but not the adaptive immune system, which is not reversed immediately after withdrawal. This alcohol-induced status of the immune system predisposes to infections and sepsis by blunting initial response to the pathogens.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Allemagne</li>
</country>
<region>
<li>District de Leipzig</li>
<li>Saxe (Land)</li>
</region>
<settlement>
<li>Leipzig</li>
</settlement>
</list>
<tree>
<noCountry>
<name sortKey="Schu Tt, Christine" sort="Schu Tt, Christine" uniqKey="Schu Tt C" first="Christine" last="Schu Tt">Christine Schu Tt</name>
<name sortKey="Witte, Karin" sort="Witte, Karin" uniqKey="Witte K" first="Karin" last="Witte">Karin Witte</name>
</noCountry>
<country name="Allemagne">
<noRegion>
<name sortKey="Frank, Johannes" sort="Frank, Johannes" uniqKey="Frank J" first="Johannes" last="Frank">Johannes Frank</name>
</noRegion>
<name sortKey="Schro Dl, Wieland" sort="Schro Dl, Wieland" uniqKey="Schro Dl W" first="Wieland" last="Schro Dl">Wieland Schro Dl</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/corpus/SchutzV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000858 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Musique
   |area=    SchutzV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     ISTEX:A04415F38A8A223D40D15B4419C207785534070F
   |texte=   CHRONIC ALCOHOLISM CAUSES DELETERIOUS CONDITIONING OF INNATE IMMUNITY
}}

Wicri

This area was generated with Dilib version V0.6.20.
Data generation: Sun Apr 10 01:23:10 2016. Site generation: Fri Aug 18 21:45:27 2017