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Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial.

Identifieur interne : 000078 ( PubMed/Curation ); précédent : 000077; suivant : 000079

Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial.

Auteurs : Jason H Y. Wu ; Roberto Marchioli ; Maria G. Silletta ; Serge Masson ; Frank W. Sellke ; Peter Libby ; Ginger L. Milne ; Nancy J. Brown ; Federico Lombardi ; Ralph J. Damiano [États-Unis] ; Joann Marsala [États-Unis] ; Mauro Rinaldi ; Alberto Domenech ; Caterina Simon ; Luigi Tavazzi ; Dariush Mozaffarian

Source :

RBID : pubmed:25994442

English descriptors

Abstract

Animal study results point to oxidative stress as a key mechanism triggering postoperative atrial fibrillation (PoAF), yet the extent to which specific biomarkers of oxidative stress might relate to PoAF risk in humans remains speculative.

DOI: 10.1161/JAHA.115.001886
PubMed: 25994442

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Jason H Y. Wu
<affiliation>
<nlm:affiliation>George Institute for Global Health, Sydney Medical School, The University of Sydney, New South Wales, Australia (J.Y.W.).</nlm:affiliation>
<wicri:noCountry code="subField">Australia (J.Y.W.).</wicri:noCountry>
</affiliation>
Roberto Marchioli
<affiliation>
<nlm:affiliation>Hematology-Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy (R.M.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (R.M.).</wicri:noCountry>
</affiliation>
Maria G. Silletta
<affiliation>
<nlm:affiliation>Laboratory of Clinical Epidemiology of Cardiovascular Disease, Fondazione Mario Negri Sud, Santa Maria Imbaro, Italy (M.G.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (M.G.S.).</wicri:noCountry>
</affiliation>
Serge Masson
<affiliation>
<nlm:affiliation>Department of Cardiovascular Research, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy (S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (S.M.).</wicri:noCountry>
</affiliation>
Frank W. Sellke
<affiliation>
<nlm:affiliation>Division of Cardiothoracic Surgery, Cardiovascular Research Center, Brown University Warren Alpert School of Medicine, Providence, RI (F.W.S.).</nlm:affiliation>
<wicri:noCountry code="subField">RI (F.W.S.).</wicri:noCountry>
</affiliation>
Peter Libby
<affiliation>
<nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.L.).</nlm:affiliation>
<wicri:noCountry code="subField">MA (P.L.).</wicri:noCountry>
</affiliation>
Ginger L. Milne
<affiliation>
<nlm:affiliation>Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (G.L.M.).</nlm:affiliation>
<wicri:noCountry code="subField">TN (G.L.M.).</wicri:noCountry>
</affiliation>
Nancy J. Brown
<affiliation>
<nlm:affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (N.J.B.).</nlm:affiliation>
<wicri:noCountry code="subField">TN (N.J.B.).</wicri:noCountry>
</affiliation>
Federico Lombardi
<affiliation>
<nlm:affiliation>U.O.C. di Malattie Cardiovascolari, Fondazione IRCCS Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Communita, Universita degli Studi di Milano, Italy (F.L.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (F.L.).</wicri:noCountry>
</affiliation>
Mauro Rinaldi
<affiliation>
<nlm:affiliation>Division of Cardiac Surgery, Citta'della Salute e della Scienza, University of Turin, Italy (M.R.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (M.R.).</wicri:noCountry>
</affiliation>
Alberto Domenech
<affiliation>
<nlm:affiliation>Department of Cardiovascular Surgery, Italian Hospital of Buenos Aires, Argentina (A.D.).</nlm:affiliation>
<wicri:noCountry code="subField">Argentina (A.D.).</wicri:noCountry>
</affiliation>
Caterina Simon
<affiliation>
<nlm:affiliation>Cardiovascular Department, Cardiac Surgery, Ospedali Riuniti di Bergamo, Italy (C.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (C.S.).</wicri:noCountry>
</affiliation>
Luigi Tavazzi
<affiliation>
<nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research-E.S. Health Science Foundation, Cotignola, Italy (L.T.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (L.T.).</wicri:noCountry>
</affiliation>
Dariush Mozaffarian
<affiliation>
<nlm:affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.).</nlm:affiliation>
<wicri:noCountry code="subField">MA (D.M.).</wicri:noCountry>
</affiliation>

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<wicri:noCountry code="subField">Argentina (A.D.).</wicri:noCountry>
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<name sortKey="Simon, Caterina" sort="Simon, Caterina" uniqKey="Simon C" first="Caterina" last="Simon">Caterina Simon</name>
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<nlm:affiliation>Cardiovascular Department, Cardiac Surgery, Ospedali Riuniti di Bergamo, Italy (C.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (C.S.).</wicri:noCountry>
</affiliation>
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<name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name>
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<nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research-E.S. Health Science Foundation, Cotignola, Italy (L.T.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (L.T.).</wicri:noCountry>
</affiliation>
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<wicri:noCountry code="subField">MA (D.M.).</wicri:noCountry>
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<title xml:lang="en">Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial.</title>
<author>
<name sortKey="Wu, Jason H Y" sort="Wu, Jason H Y" uniqKey="Wu J" first="Jason H Y" last="Wu">Jason H Y. Wu</name>
<affiliation>
<nlm:affiliation>George Institute for Global Health, Sydney Medical School, The University of Sydney, New South Wales, Australia (J.Y.W.).</nlm:affiliation>
<wicri:noCountry code="subField">Australia (J.Y.W.).</wicri:noCountry>
</affiliation>
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<name sortKey="Marchioli, Roberto" sort="Marchioli, Roberto" uniqKey="Marchioli R" first="Roberto" last="Marchioli">Roberto Marchioli</name>
<affiliation>
<nlm:affiliation>Hematology-Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy (R.M.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (R.M.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Silletta, Maria G" sort="Silletta, Maria G" uniqKey="Silletta M" first="Maria G" last="Silletta">Maria G. Silletta</name>
<affiliation>
<nlm:affiliation>Laboratory of Clinical Epidemiology of Cardiovascular Disease, Fondazione Mario Negri Sud, Santa Maria Imbaro, Italy (M.G.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (M.G.S.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Masson, Serge" sort="Masson, Serge" uniqKey="Masson S" first="Serge" last="Masson">Serge Masson</name>
<affiliation>
<nlm:affiliation>Department of Cardiovascular Research, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy (S.M.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (S.M.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Sellke, Frank W" sort="Sellke, Frank W" uniqKey="Sellke F" first="Frank W" last="Sellke">Frank W. Sellke</name>
<affiliation>
<nlm:affiliation>Division of Cardiothoracic Surgery, Cardiovascular Research Center, Brown University Warren Alpert School of Medicine, Providence, RI (F.W.S.).</nlm:affiliation>
<wicri:noCountry code="subField">RI (F.W.S.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Libby, Peter" sort="Libby, Peter" uniqKey="Libby P" first="Peter" last="Libby">Peter Libby</name>
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<nlm:affiliation>Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.L.).</nlm:affiliation>
<wicri:noCountry code="subField">MA (P.L.).</wicri:noCountry>
</affiliation>
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<name sortKey="Milne, Ginger L" sort="Milne, Ginger L" uniqKey="Milne G" first="Ginger L" last="Milne">Ginger L. Milne</name>
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<nlm:affiliation>Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (G.L.M.).</nlm:affiliation>
<wicri:noCountry code="subField">TN (G.L.M.).</wicri:noCountry>
</affiliation>
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<name sortKey="Brown, Nancy J" sort="Brown, Nancy J" uniqKey="Brown N" first="Nancy J" last="Brown">Nancy J. Brown</name>
<affiliation>
<nlm:affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (N.J.B.).</nlm:affiliation>
<wicri:noCountry code="subField">TN (N.J.B.).</wicri:noCountry>
</affiliation>
</author>
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<name sortKey="Lombardi, Federico" sort="Lombardi, Federico" uniqKey="Lombardi F" first="Federico" last="Lombardi">Federico Lombardi</name>
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<nlm:affiliation>U.O.C. di Malattie Cardiovascolari, Fondazione IRCCS Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Communita, Universita degli Studi di Milano, Italy (F.L.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (F.L.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Damiano, Ralph J" sort="Damiano, Ralph J" uniqKey="Damiano R" first="Ralph J" last="Damiano">Ralph J. Damiano</name>
<affiliation wicri:level="4">
<nlm:affiliation>Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO (R.J.D., J.M.).</nlm:affiliation>
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<name sortKey="Marsala, Joann" sort="Marsala, Joann" uniqKey="Marsala J" first="Joann" last="Marsala">Joann Marsala</name>
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<nlm:affiliation>Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO (R.J.D., J.M.).</nlm:affiliation>
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<name sortKey="Rinaldi, Mauro" sort="Rinaldi, Mauro" uniqKey="Rinaldi M" first="Mauro" last="Rinaldi">Mauro Rinaldi</name>
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<nlm:affiliation>Division of Cardiac Surgery, Citta'della Salute e della Scienza, University of Turin, Italy (M.R.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (M.R.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Domenech, Alberto" sort="Domenech, Alberto" uniqKey="Domenech A" first="Alberto" last="Domenech">Alberto Domenech</name>
<affiliation>
<nlm:affiliation>Department of Cardiovascular Surgery, Italian Hospital of Buenos Aires, Argentina (A.D.).</nlm:affiliation>
<wicri:noCountry code="subField">Argentina (A.D.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Simon, Caterina" sort="Simon, Caterina" uniqKey="Simon C" first="Caterina" last="Simon">Caterina Simon</name>
<affiliation>
<nlm:affiliation>Cardiovascular Department, Cardiac Surgery, Ospedali Riuniti di Bergamo, Italy (C.S.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (C.S.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Tavazzi, Luigi" sort="Tavazzi, Luigi" uniqKey="Tavazzi L" first="Luigi" last="Tavazzi">Luigi Tavazzi</name>
<affiliation>
<nlm:affiliation>Maria Cecilia Hospital, GVM Care & Research-E.S. Health Science Foundation, Cotignola, Italy (L.T.).</nlm:affiliation>
<wicri:noCountry code="subField">Italy (L.T.).</wicri:noCountry>
</affiliation>
</author>
<author>
<name sortKey="Mozaffarian, Dariush" sort="Mozaffarian, Dariush" uniqKey="Mozaffarian D" first="Dariush" last="Mozaffarian">Dariush Mozaffarian</name>
<affiliation>
<nlm:affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.).</nlm:affiliation>
<wicri:noCountry code="subField">MA (D.M.).</wicri:noCountry>
</affiliation>
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<series>
<title level="j">Journal of the American Heart Association</title>
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<keywords scheme="KwdEn" xml:lang="en">
<term>Atrial Fibrillation (epidemiology)</term>
<term>Atrial Fibrillation (etiology)</term>
<term>Atrial Fibrillation (physiopathology)</term>
<term>Atrial Fibrillation (prevention & control)</term>
<term>Biomarkers (blood)</term>
<term>Dietary Fats, Unsaturated (therapeutic use)</term>
<term>Electrocardiography</term>
<term>F2-Isoprostanes (blood)</term>
<term>Fatty Acids, Omega-3 (administration & dosage)</term>
<term>Fatty Acids, Omega-3 (therapeutic use)</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Isoprostanes (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Oxidative Stress</term>
<term>Postoperative Complications (diet therapy)</term>
<term>Postoperative Complications (prevention & control)</term>
<term>Postoperative Period</term>
<term>Treatment Outcome</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en">
<term>Fatty Acids, Omega-3</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Biomarkers</term>
<term>F2-Isoprostanes</term>
<term>Isoprostanes</term>
</keywords>
<keywords scheme="MESH" qualifier="diet therapy" xml:lang="en">
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en">
<term>Atrial Fibrillation</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Atrial Fibrillation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Atrial Fibrillation</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en">
<term>Atrial Fibrillation</term>
<term>Postoperative Complications</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Dietary Fats, Unsaturated</term>
<term>Fatty Acids, Omega-3</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Electrocardiography</term>
<term>Female</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Oxidative Stress</term>
<term>Postoperative Period</term>
<term>Treatment Outcome</term>
</keywords>
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<front>
<div type="abstract" xml:lang="en">Animal study results point to oxidative stress as a key mechanism triggering postoperative atrial fibrillation (PoAF), yet the extent to which specific biomarkers of oxidative stress might relate to PoAF risk in humans remains speculative.</div>
</front>
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<Month>05</Month>
<Day>21</Day>
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</JournalIssue>
<Title>Journal of the American Heart Association</Title>
<ISOAbbreviation>J Am Heart Assoc</ISOAbbreviation>
</Journal>
<ArticleTitle>Oxidative Stress Biomarkers and Incidence of Postoperative Atrial Fibrillation in the Omega-3 Fatty Acids for Prevention of Postoperative Atrial Fibrillation (OPERA) Trial.</ArticleTitle>
<Pagination>
<MedlinePgn></MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.1161/JAHA.115.001886</ELocationID>
<ELocationID EIdType="pii" ValidYN="Y">e001886</ELocationID>
<Abstract>
<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Animal study results point to oxidative stress as a key mechanism triggering postoperative atrial fibrillation (PoAF), yet the extent to which specific biomarkers of oxidative stress might relate to PoAF risk in humans remains speculative.</AbstractText>
<AbstractText Label="METHODS AND RESULTS" NlmCategory="RESULTS">We assessed the association of validated, fatty acid-derived oxidative stress biomarkers (F2-isoprostanes, isofurans, and F3-isoprostanes) in plasma and urine, with incident PoAF among 551 cardiac surgery patients. Biomarkers were measured at enrollment, the end of surgery, and postoperative day 2. PoAF lasting ≥30 seconds was confirmed with rhythm strip or electrocardiography and centrally adjudicated. Outcomes were assessed until hospital discharge or postoperative day 10, whichever occurred first. Urine level of each oxidative stress biomarker rose at the end of surgery (2- to 3-fold over baseline, P<0.001) and subsequently declined to concentrations comparable to baseline by postoperative day 2. In contrast, plasma concentrations remained relatively stable throughout the perioperative course. Urine F2-isoprostanes and isofurans at the end of surgery were 20% and 50% higher in subjects who developed PoAF (P≤0.009). While baseline biomarker levels did not associate significantly with PoAF, end of surgery and postoperative day 2 isoprostanes and isofurans demonstrated relatively linear associations with PoAF. For example, the end of surgery extreme quartile multivariate adjusted OR (95% CI) for urine isofurans and F3-isoprostanes were 1.95 (1.05 to 3.62; P for trend=0.01) and 2.10 (1.04 to 2.25, P for trend=0.04), respectively. The associations of biomarkers with PoAF varied little by demographics, surgery type, and medication use (P≥0.29 for each).</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These novel results add to accumulating evidence supporting the likely key pathogenic role of elevated oxidative stress in PoAF.</AbstractText>
<AbstractText Label="CLINICAL TRIAL REGISTRATION" NlmCategory="BACKGROUND">URL: Clinicaltrials.gov Unique identifier: NCT00970489.</AbstractText>
<CopyrightInformation>© 2015 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y">
<Author ValidYN="Y">
<LastName>Wu</LastName>
<ForeName>Jason H Y</ForeName>
<Initials>JH</Initials>
<AffiliationInfo>
<Affiliation>George Institute for Global Health, Sydney Medical School, The University of Sydney, New South Wales, Australia (J.Y.W.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Marchioli</LastName>
<ForeName>Roberto</ForeName>
<Initials>R</Initials>
<AffiliationInfo>
<Affiliation>Hematology-Oncology Therapeutic Delivery Unit, Quintiles, Milan, Italy (R.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Silletta</LastName>
<ForeName>Maria G</ForeName>
<Initials>MG</Initials>
<AffiliationInfo>
<Affiliation>Laboratory of Clinical Epidemiology of Cardiovascular Disease, Fondazione Mario Negri Sud, Santa Maria Imbaro, Italy (M.G.S.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Masson</LastName>
<ForeName>Serge</ForeName>
<Initials>S</Initials>
<AffiliationInfo>
<Affiliation>Department of Cardiovascular Research, IRCCS-Istituto di Ricerche Farmacologiche "Mario Negri", Milan, Italy (S.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Sellke</LastName>
<ForeName>Frank W</ForeName>
<Initials>FW</Initials>
<AffiliationInfo>
<Affiliation>Division of Cardiothoracic Surgery, Cardiovascular Research Center, Brown University Warren Alpert School of Medicine, Providence, RI (F.W.S.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Libby</LastName>
<ForeName>Peter</ForeName>
<Initials>P</Initials>
<AffiliationInfo>
<Affiliation>Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (P.L.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Milne</LastName>
<ForeName>Ginger L</ForeName>
<Initials>GL</Initials>
<AffiliationInfo>
<Affiliation>Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (G.L.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Brown</LastName>
<ForeName>Nancy J</ForeName>
<Initials>NJ</Initials>
<AffiliationInfo>
<Affiliation>Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (N.J.B.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Lombardi</LastName>
<ForeName>Federico</ForeName>
<Initials>F</Initials>
<AffiliationInfo>
<Affiliation>U.O.C. di Malattie Cardiovascolari, Fondazione IRCCS Ospedale Maggiore Policlinico, Dipartimento di Scienze Cliniche e di Communita, Universita degli Studi di Milano, Italy (F.L.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Damiano</LastName>
<ForeName>Ralph J</ForeName>
<Initials>RJ</Initials>
<Suffix>Jr</Suffix>
<AffiliationInfo>
<Affiliation>Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO (R.J.D., J.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Marsala</LastName>
<ForeName>Joann</ForeName>
<Initials>J</Initials>
<AffiliationInfo>
<Affiliation>Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO (R.J.D., J.M.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Rinaldi</LastName>
<ForeName>Mauro</ForeName>
<Initials>M</Initials>
<AffiliationInfo>
<Affiliation>Division of Cardiac Surgery, Citta'della Salute e della Scienza, University of Turin, Italy (M.R.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Domenech</LastName>
<ForeName>Alberto</ForeName>
<Initials>A</Initials>
<AffiliationInfo>
<Affiliation>Department of Cardiovascular Surgery, Italian Hospital of Buenos Aires, Argentina (A.D.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Simon</LastName>
<ForeName>Caterina</ForeName>
<Initials>C</Initials>
<AffiliationInfo>
<Affiliation>Cardiovascular Department, Cardiac Surgery, Ospedali Riuniti di Bergamo, Italy (C.S.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Tavazzi</LastName>
<ForeName>Luigi</ForeName>
<Initials>L</Initials>
<AffiliationInfo>
<Affiliation>Maria Cecilia Hospital, GVM Care & Research-E.S. Health Science Foundation, Cotignola, Italy (L.T.).</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y">
<LastName>Mozaffarian</LastName>
<ForeName>Dariush</ForeName>
<Initials>D</Initials>
<AffiliationInfo>
<Affiliation>Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA (D.M.).</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<DataBankList CompleteYN="Y">
<DataBank>
<DataBankName>ClinicalTrials.gov</DataBankName>
<AccessionNumberList>
<AccessionNumber>NCT00970489</AccessionNumber>
</AccessionNumberList>
</DataBank>
</DataBankList>
<GrantList CompleteYN="Y">
<Grant>
<GrantID>1 RC2 HL101816</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant>
<GrantID>R01HL085710</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
<Grant>
<GrantID>RC2 HL101816</GrantID>
<Acronym>HL</Acronym>
<Agency>NHLBI NIH HHS</Agency>
<Country>United States</Country>
</Grant>
</GrantList>
<PublicationTypeList>
<PublicationType UI="D016430">Clinical Trial</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic">
<Year>2015</Year>
<Month>05</Month>
<Day>20</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo>
<Country>England</Country>
<MedlineTA>J Am Heart Assoc</MedlineTA>
<NlmUniqueID>101580524</NlmUniqueID>
<ISSNLinking>2047-9980</ISSNLinking>
</MedlineJournalInfo>
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<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D004042">Dietary Fats, Unsaturated</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D028441">F2-Isoprostanes</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D015525">Fatty Acids, Omega-3</NameOfSubstance>
</Chemical>
<Chemical>
<RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D028421">Isoprostanes</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
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<MeshHeadingList>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D001281">Atrial Fibrillation</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000453">epidemiology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName>
<QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D015415">Biomarkers</DescriptorName>
<QualifierName MajorTopicYN="Y" UI="Q000097">blood</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D004042">Dietary Fats, Unsaturated</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D004562">Electrocardiography</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D028441">F2-Isoprostanes</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D015525">Fatty Acids, Omega-3</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000008">administration & dosage</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D015994">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D028421">Isoprostanes</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="Y" UI="D018384">Oxidative Stress</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D011183">Postoperative Complications</DescriptorName>
<QualifierName MajorTopicYN="N" UI="Q000178">diet therapy</QualifierName>
<QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D011184">Postoperative Period</DescriptorName>
</MeshHeading>
<MeshHeading>
<DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<OtherID Source="NLM">PMC4599415</OtherID>
<KeywordList Owner="NOTNLM">
<Keyword MajorTopicYN="N">atrial fibrillation</Keyword>
<Keyword MajorTopicYN="N">cardiac surgery</Keyword>
<Keyword MajorTopicYN="N">isofurans</Keyword>
<Keyword MajorTopicYN="N">isoprostanes</Keyword>
<Keyword MajorTopicYN="N">oxidative stress</Keyword>
</KeywordList>
</MedlineCitation>
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<Year>2015</Year>
<Month>5</Month>
<Day>22</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<PubMedPubDate PubStatus="pubmed">
<Year>2015</Year>
<Month>5</Month>
<Day>23</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline">
<Year>2016</Year>
<Month>2</Month>
<Day>6</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>epublish</PublicationStatus>
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<ArticleId IdType="pii">JAHA.115.001886</ArticleId>
<ArticleId IdType="doi">10.1161/JAHA.115.001886</ArticleId>
<ArticleId IdType="pubmed">25994442</ArticleId>
<ArticleId IdType="pmc">PMC4599415</ArticleId>
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