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Interleukin-23 in early disease development in rheumatoid arthritis.

Identifieur interne : 000086 ( PubMed/Checkpoint ); précédent : 000085; suivant : 000087

Interleukin-23 in early disease development in rheumatoid arthritis.

Auteurs : T. Andersen ; M. Hvid ; C. Johansen ; K. Stengaard-Pedersen ; M L Hetland ; K. H Rslev-Petersen ; P. Junker ; M. Stergaard ; B. Deleuran

Source :

RBID : pubmed:26087654

Abstract

To investigate the levels of interleukin (IL)-23 in patients with early rheumatoid arthritis (eRA) and the effect of anti-tumour necrosis factor (anti-TNF)-α treatment on IL-23 levels.

DOI: 10.3109/03009742.2015.1033007
PubMed: 26087654


Affiliations:


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pubmed:26087654

Le document en format XML

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<title xml:lang="en">Interleukin-23 in early disease development in rheumatoid arthritis.</title>
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<name sortKey="Andersen, T" sort="Andersen, T" uniqKey="Andersen T" first="T" last="Andersen">T. Andersen</name>
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<name sortKey="Hvid, M" sort="Hvid, M" uniqKey="Hvid M" first="M" last="Hvid">M. Hvid</name>
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<name sortKey="Johansen, C" sort="Johansen, C" uniqKey="Johansen C" first="C" last="Johansen">C. Johansen</name>
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<name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name>
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<name sortKey="Hetland, M L" sort="Hetland, M L" uniqKey="Hetland M" first="M L" last="Hetland">M L Hetland</name>
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<name sortKey="H Rslev Petersen, K" sort="H Rslev Petersen, K" uniqKey="H Rslev Petersen K" first="K" last="H Rslev-Petersen">K. H Rslev-Petersen</name>
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<name sortKey="Junker, P" sort="Junker, P" uniqKey="Junker P" first="P" last="Junker">P. Junker</name>
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<name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name>
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<name sortKey="Deleuran, B" sort="Deleuran, B" uniqKey="Deleuran B" first="B" last="Deleuran">B. Deleuran</name>
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<title xml:lang="en">Interleukin-23 in early disease development in rheumatoid arthritis.</title>
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<name sortKey="Andersen, T" sort="Andersen, T" uniqKey="Andersen T" first="T" last="Andersen">T. Andersen</name>
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<name sortKey="Hvid, M" sort="Hvid, M" uniqKey="Hvid M" first="M" last="Hvid">M. Hvid</name>
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<name sortKey="Johansen, C" sort="Johansen, C" uniqKey="Johansen C" first="C" last="Johansen">C. Johansen</name>
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<name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name>
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<name sortKey="Hetland, M L" sort="Hetland, M L" uniqKey="Hetland M" first="M L" last="Hetland">M L Hetland</name>
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<name sortKey="H Rslev Petersen, K" sort="H Rslev Petersen, K" uniqKey="H Rslev Petersen K" first="K" last="H Rslev-Petersen">K. H Rslev-Petersen</name>
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<name sortKey="Junker, P" sort="Junker, P" uniqKey="Junker P" first="P" last="Junker">P. Junker</name>
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<name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name>
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<name sortKey="Deleuran, B" sort="Deleuran, B" uniqKey="Deleuran B" first="B" last="Deleuran">B. Deleuran</name>
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<series>
<title level="j">Scandinavian journal of rheumatology</title>
<idno type="e-ISSN">1502-7732</idno>
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<date when="2015" type="published">2015</date>
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<front>
<div type="abstract" xml:lang="en">To investigate the levels of interleukin (IL)-23 in patients with early rheumatoid arthritis (eRA) and the effect of anti-tumour necrosis factor (anti-TNF)-α treatment on IL-23 levels.</div>
</front>
</TEI>
<pubmed>
<MedlineCitation Owner="NLM" Status="In-Process">
<PMID Version="1">26087654</PMID>
<DateCreated>
<Year>2016</Year>
<Month>02</Month>
<Day>18</Day>
</DateCreated>
<Article PubModel="Print">
<Journal>
<ISSN IssnType="Electronic">1502-7732</ISSN>
<JournalIssue CitedMedium="Internet">
<Volume>44</Volume>
<Issue>6</Issue>
<PubDate>
<Year>2015</Year>
</PubDate>
</JournalIssue>
<Title>Scandinavian journal of rheumatology</Title>
<ISOAbbreviation>Scand. J. Rheumatol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Interleukin-23 in early disease development in rheumatoid arthritis.</ArticleTitle>
<Pagination>
<MedlinePgn>438-42</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To investigate the levels of interleukin (IL)-23 in patients with early rheumatoid arthritis (eRA) and the effect of anti-tumour necrosis factor (anti-TNF)-α treatment on IL-23 levels.</AbstractText>
<AbstractText Label="METHOD" NlmCategory="METHODS">Treatment-naïve eRA patients from the OPERA cohort were included (n = 151). Patients were randomized to methotrexate (MTX) plus adalimumab (ADA; n = 75) or MTX plus placebo-ADA (PLA; n = 76). Plasma samples were obtained at baseline and at months 3, 6, and 12 together with values for C-reactive protein (CRP), the 28-joint Disease Activity Score based on CRP (DAS28CRP), scores on the Clinical Disease Activity Index (CDAI) and the Simplified Disease Activity Index (SDAI), visual analogue scale (VAS) for pain/fatigue/physician global and total Sharp/van der Heijde score (TSS). IL-23 was measured at each time point.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">IL-23 levels decreased significantly in the ADA group from 20.6 pg/mL (IQR 13.1-32.7 pg/mL) at baseline to 18 pg/mL (IQR 7.2-25.0 pg/mL) at 12 months (p < 0.01). No significant decrease in IL-23 level was observed in the PLA group. No associations between baseline IL-23 levels and measures of disease activity (DAS28CRP, CRP, CDAI, or SDAI) at 12 or 24 months were present in the treatment groups. Baseline IL-23 correlated inversely with changes in TSS and symptom duration before diagnosis.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Our data show increased baseline levels and a significant decrease in IL-23 levels in eRA patients treated with anti-TNF-α. The inverse correlation with duration of symptoms before diagnosis supports the importance of IL-23 in the preclinical disease development of RA.</AbstractText>
</Abstract>
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<Language>eng</Language>
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<PublicationType UI="D016428">Journal Article</PublicationType>
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<Country>England</Country>
<MedlineTA>Scand J Rheumatol</MedlineTA>
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<name sortKey=" Stergaard, M" sort=" Stergaard, M" uniqKey=" Stergaard M" first="M" last=" Stergaard">M. Stergaard</name>
<name sortKey="Andersen, T" sort="Andersen, T" uniqKey="Andersen T" first="T" last="Andersen">T. Andersen</name>
<name sortKey="Deleuran, B" sort="Deleuran, B" uniqKey="Deleuran B" first="B" last="Deleuran">B. Deleuran</name>
<name sortKey="H Rslev Petersen, K" sort="H Rslev Petersen, K" uniqKey="H Rslev Petersen K" first="K" last="H Rslev-Petersen">K. H Rslev-Petersen</name>
<name sortKey="Hetland, M L" sort="Hetland, M L" uniqKey="Hetland M" first="M L" last="Hetland">M L Hetland</name>
<name sortKey="Hvid, M" sort="Hvid, M" uniqKey="Hvid M" first="M" last="Hvid">M. Hvid</name>
<name sortKey="Johansen, C" sort="Johansen, C" uniqKey="Johansen C" first="C" last="Johansen">C. Johansen</name>
<name sortKey="Junker, P" sort="Junker, P" uniqKey="Junker P" first="P" last="Junker">P. Junker</name>
<name sortKey="Stengaard Pedersen, K" sort="Stengaard Pedersen, K" uniqKey="Stengaard Pedersen K" first="K" last="Stengaard-Pedersen">K. Stengaard-Pedersen</name>
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