OperaV1, PascalFrancis, Curation, bibRecord, 000419

Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

Identifieur interne : 000419 ( PascalFrancis/Curation ); précédent : 000418; suivant : 000420

Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

Auteurs : Riitta-Liisa Vasunta [Finlande] ; Y. Antero Kes Niemi [Finlande] ; Antti Ylitalo [Finlande] ; Olavi Ukkola [Finlande]

Source :

American journal of hypertension [ 0895-7061 ] ; 2012.

RBID : Pascal:12-0150597

Descripteurs français

Pascal (Inist)
- Athérosclérose, Cardiopathie coronaire, Hypertension artérielle, Pathologie de l'appareil circulatoire, Carotide, Pression artérielle, Pression sanguine, Monitorage.

English descriptors

KwdEn :
- Arterial pressure, Atherosclerosis, Blood pressure, Cardiovascular disease, Carotid, Coronary heart disease, Hypertension, Monitoring.

Abstract

BACKGROUND The lack of dropping in night-time blood pressure of 10% or more (nondipping) seems to associate with cardiovascular risk factors. The relationship between the dipping pattern and atherosclerosis is not clear. The night-time systolic blood pressure (SBP) determines the dipping status. METHODS We investigated the connection between intima-media thickness (IMT) and dipping status (dipper, nondipper) taking into account covariates known to associate with hypertension and early atherosclerosis. 900 middle-aged (446 men, 454 women) were studied, 51 % of them using blood pressure lowering medication. IMTwas measured by a duplex ultrasound from the common carotid artery (CCA), the internal carotid artery (ICA) and the bifurcation enlargement (BIF).The mean IMT was defined as the mean of ICA, BIF, and the 3 highest CCA measurements. Ambulatory blood pressure (ABP) was recorded using the fully automatic SpaceLabs90207 oscillometric unit. RESULTS Nondippers had lower high-density lipoprotein cholesterol (P= 0.02), higher triglycerides (P<0.01), body mass index (P<0.0001) and higher night-time blood pressure (P < 0.0001) than dippers and they were more often nonsmokers (P=0.01). Increased mean IMT in carotid artery was associated with ABP nondipping pattern (P < 0.01) regardless of conventional cardiovascular risk factors, antihypertensive or lipid lowering medications. Nocturnal blood pressure elevation was independently associated with IMT (P < 0.01). When sexes were analysed separately, the association was seen in men but was only a trend among women. CONCLUSIONS Nondipping status in ABP monitoring is independently associated with early atherosclerosis. Whether nondipping pattern is a predictor of atherosclerosis remains to be explored in a future prospective follow-up of this cohort.

A01	`01`	`1`		`@0 0895-7061`
A03		`1`		`@0 Am. j. hypertens.`
A05				`@2 25`
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A08	`01`	`1`	`ENG`	`@1 Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study`
A11	`01`	`1`		`@1 VASUNTA (Riitta-Liisa)`
A11	`02`	`1`		`@1 ANTERO KESÄNIEMI (Y.)`
A11	`03`	`1`		`@1 YLITALO (Antti)`
A11	`04`	`1`		`@1 UKKOLA (Olavi)`
A14	`01`			`@1 Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital @2 Oulu @3 FIN @Z 1 aut. @Z 2 aut. @Z 4 aut.`
A14	`02`			`@1 Department of Internal Medicine, Jyväskylä Central Hospital, Keskussairaalantie 19 @2 Jyväskylä @3 FIN @Z 1 aut.`
A14	`03`			`@1 Department of Cardiology, Satakunta Central Hospital Sairaalatie 3 @2 Pori @3 FIN @Z 3 aut.`
A20				`@1 60-66`
A21				`@1 2012`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 21579 @5 354000509735290140`
A44				`@0 0000 @1 © 2012 INIST-CNRS. All rights reserved.`
A45				`@0 28 ref.`
A47	`01`	`1`		`@0 12-0150597`
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A61				`@0 A`
A64	`01`	`1`		`@0 American journal of hypertension`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 BACKGROUND The lack of dropping in night-time blood pressure of 10% or more (nondipping) seems to associate with cardiovascular risk factors. The relationship between the dipping pattern and atherosclerosis is not clear. The night-time systolic blood pressure (SBP) determines the dipping status. METHODS We investigated the connection between intima-media thickness (IMT) and dipping status (dipper, nondipper) taking into account covariates known to associate with hypertension and early atherosclerosis. 900 middle-aged (446 men, 454 women) were studied, 51 % of them using blood pressure lowering medication. IMTwas measured by a duplex ultrasound from the common carotid artery (CCA), the internal carotid artery (ICA) and the bifurcation enlargement (BIF).The mean IMT was defined as the mean of ICA, BIF, and the 3 highest CCA measurements. Ambulatory blood pressure (ABP) was recorded using the fully automatic SpaceLabs90207 oscillometric unit. RESULTS Nondippers had lower high-density lipoprotein cholesterol (P= 0.02), higher triglycerides (P<0.01), body mass index (P<0.0001) and higher night-time blood pressure (P < 0.0001) than dippers and they were more often nonsmokers (P=0.01). Increased mean IMT in carotid artery was associated with ABP nondipping pattern (P < 0.01) regardless of conventional cardiovascular risk factors, antihypertensive or lipid lowering medications. Nocturnal blood pressure elevation was independently associated with IMT (P < 0.01). When sexes were analysed separately, the association was seen in men but was only a trend among women. CONCLUSIONS Nondipping status in ABP monitoring is independently associated with early atherosclerosis. Whether nondipping pattern is a predictor of atherosclerosis remains to be explored in a future prospective follow-up of this cohort.
C02	`01`	`X`		`@0 002B12B05`
C02	`02`	`X`		`@0 002B12B01`
C03	`01`	`X`	`FRE`	`@0 Athérosclérose @2 NM @5 01`
C03	`01`	`X`	`ENG`	`@0 Atherosclerosis @2 NM @5 01`
C03	`01`	`X`	`SPA`	`@0 Ateroesclerosis @2 NM @5 01`
C03	`02`	`X`	`FRE`	`@0 Cardiopathie coronaire @5 02`
C03	`02`	`X`	`ENG`	`@0 Coronary heart disease @5 02`
C03	`02`	`X`	`SPA`	`@0 Cardiopatía coronaria @5 02`
C03	`03`	`X`	`FRE`	`@0 Hypertension artérielle @5 03`
C03	`03`	`X`	`ENG`	`@0 Hypertension @5 03`
C03	`03`	`X`	`SPA`	`@0 Hipertensión arterial @5 03`
C03	`04`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 04`
C03	`04`	`X`	`ENG`	`@0 Cardiovascular disease @5 04`
C03	`04`	`X`	`SPA`	`@0 Aparato circulatorio patología @5 04`
C03	`05`	`X`	`FRE`	`@0 Carotide @5 09`
C03	`05`	`X`	`ENG`	`@0 Carotid @5 09`
C03	`05`	`X`	`SPA`	`@0 Carótida @5 09`
C03	`06`	`X`	`FRE`	`@0 Pression artérielle @5 10`
C03	`06`	`X`	`ENG`	`@0 Arterial pressure @5 10`
C03	`06`	`X`	`SPA`	`@0 Presión arterial @5 10`
C03	`07`	`X`	`FRE`	`@0 Pression sanguine @5 11`
C03	`07`	`X`	`ENG`	`@0 Blood pressure @5 11`
C03	`07`	`X`	`SPA`	`@0 Presión sanguínea @5 11`
C03	`08`	`X`	`FRE`	`@0 Monitorage @5 12`
C03	`08`	`X`	`ENG`	`@0 Monitoring @5 12`
C03	`08`	`X`	`SPA`	`@0 Monitoreo @5 12`
C07	`01`	`X`	`FRE`	`@0 Pathologie des vaisseaux sanguins @5 37`
C07	`01`	`X`	`ENG`	`@0 Vascular disease @5 37`
C07	`01`	`X`	`SPA`	`@0 Vaso sanguíneo patología @5 37`
N21				`@1 114`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

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Le document en format XML

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<term>Carotid</term>
<term>Coronary heart disease</term>
<term>Hypertension</term>
<term>Monitoring</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Athérosclérose</term>
<term>Cardiopathie coronaire</term>
<term>Hypertension artérielle</term>
<term>Pathologie de l'appareil circulatoire</term>
<term>Carotide</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND The lack of dropping in night-time blood pressure of 10% or more (nondipping) seems to associate with cardiovascular risk factors. The relationship between the dipping pattern and atherosclerosis is not clear. The night-time systolic blood pressure (SBP) determines the dipping status. METHODS We investigated the connection between intima-media thickness (IMT) and dipping status (dipper, nondipper) taking into account covariates known to associate with hypertension and early atherosclerosis. 900 middle-aged (446 men, 454 women) were studied, 51 % of them using blood pressure lowering medication. IMTwas measured by a duplex ultrasound from the common carotid artery (CCA), the internal carotid artery (ICA) and the bifurcation enlargement (BIF).The mean IMT was defined as the mean of ICA, BIF, and the 3 highest CCA measurements. Ambulatory blood pressure (ABP) was recorded using the fully automatic SpaceLabs90207 oscillometric unit. RESULTS Nondippers had lower high-density lipoprotein cholesterol (P= 0.02), higher triglycerides (P<0.01), body mass index (P<0.0001) and higher night-time blood pressure (P < 0.0001) than dippers and they were more often nonsmokers (P=0.01). Increased mean IMT in carotid artery was associated with ABP nondipping pattern (P < 0.01) regardless of conventional cardiovascular risk factors, antihypertensive or lipid lowering medications. Nocturnal blood pressure elevation was independently associated with IMT (P < 0.01). When sexes were analysed separately, the association was seen in men but was only a trend among women. CONCLUSIONS Nondipping status in ABP monitoring is independently associated with early atherosclerosis. Whether nondipping pattern is a predictor of atherosclerosis remains to be explored in a future prospective follow-up of this cohort.</div>
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<fA05><s2>25</s2>
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<fA08 i1="01" i2="1" l="ENG"><s1>Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study</s1>
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<fA11 i1="01" i2="1"><s1>VASUNTA (Riitta-Liisa)</s1>
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<fA11 i1="02" i2="1"><s1>ANTERO KESÄNIEMI (Y.)</s1>
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<fA11 i1="03" i2="1"><s1>YLITALO (Antti)</s1>
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<fA11 i1="04" i2="1"><s1>UKKOLA (Olavi)</s1>
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<fA14 i1="01"><s1>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Internal Medicine, Jyväskylä Central Hospital, Keskussairaalantie 19</s1>
<s2>Jyväskylä</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>BACKGROUND The lack of dropping in night-time blood pressure of 10% or more (nondipping) seems to associate with cardiovascular risk factors. The relationship between the dipping pattern and atherosclerosis is not clear. The night-time systolic blood pressure (SBP) determines the dipping status. METHODS We investigated the connection between intima-media thickness (IMT) and dipping status (dipper, nondipper) taking into account covariates known to associate with hypertension and early atherosclerosis. 900 middle-aged (446 men, 454 women) were studied, 51 % of them using blood pressure lowering medication. IMTwas measured by a duplex ultrasound from the common carotid artery (CCA), the internal carotid artery (ICA) and the bifurcation enlargement (BIF).The mean IMT was defined as the mean of ICA, BIF, and the 3 highest CCA measurements. Ambulatory blood pressure (ABP) was recorded using the fully automatic SpaceLabs90207 oscillometric unit. RESULTS Nondippers had lower high-density lipoprotein cholesterol (P= 0.02), higher triglycerides (P<0.01), body mass index (P<0.0001) and higher night-time blood pressure (P < 0.0001) than dippers and they were more often nonsmokers (P=0.01). Increased mean IMT in carotid artery was associated with ABP nondipping pattern (P < 0.01) regardless of conventional cardiovascular risk factors, antihypertensive or lipid lowering medications. Nocturnal blood pressure elevation was independently associated with IMT (P < 0.01). When sexes were analysed separately, the association was seen in men but was only a trend among women. CONCLUSIONS Nondipping status in ABP monitoring is independently associated with early atherosclerosis. Whether nondipping pattern is a predictor of atherosclerosis remains to be explored in a future prospective follow-up of this cohort.</s0>
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<s5>01</s5>
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<fC03 i1="01" i2="X" l="SPA"><s0>Ateroesclerosis</s0>
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   |type=    RBID
   |clé=     Pascal:12-0150597
   |texte=   Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study
}}

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Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

Nondipping Pattern and Carotid Atherosclerosis in a Middle-Aged Population: OPERA Study

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