OperaV1, PascalFrancis, Corpus, bibRecord, 000440

Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene

Identifieur interne : 000440 ( PascalFrancis/Corpus ); précédent : 000439; suivant : 000441

Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene

Auteurs : Johanna Vartiainen ; Seppo M. Pöykkö ; Tuija R Is Nen ; Y. Antero Kes Niemi ; Olavi Ukkola

Source :

European journal of endocrinology [ 0804-4643 ] ; 2004.

RBID : Pascal:04-0282832

Descripteurs français

Pascal (Inist)
- STH, Séquence nucléotide, Séquençage, Ghréline, Récepteur biologique, Récepteur hormonal, Gène, Génétique, Endocrinologie.

English descriptors

KwdEn :
- Biological receptor, Endocrinology, Gene, Genetics, Ghrelin, Hormonal receptor, Nucleotide sequence, Sequencing, Somatotropin hormone.

Abstract

Objectives and design: Ghrelin is a novel 28 amino acid peptide which is reported to have several endocrine and non-endocrine actions. It possesses strong growth hormone (GH)-releasing activity. which is mediated via the GH secretagogue receptor type la (GHS-R1a). We hypothesised that there might be functional sequential variations in the GHS-R1a gene affecting phenotypes linked to the GH/insulin-like growth factor-I (IGF-I)-axis. Methods: To test our hypothesis we chose patients from our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study with low (n = 96) and high (n= 96) IGF-I levels. sequenced their GHS-R1a gene exons and performed association studies. Results: We found five single-nucleotide polymorphisms (SNPs) which did not change the amino acid sequence. We were unable to detect associations between the SNPs and the IGF-I plasma concentrations, but instead we showed that SNP 171C > T was associated with the values of the area under the insulin curve (AUCIN) in an oral glucose tolerance test and with IGF-binding protein-1 (IGFBP-1) concentrations (P < 0.05). SNP 477G > A was associated with the low density lipoprotein and very low density lipoprotein cholesterol plasma levels and AUCIN values (P < 0.05). Conclusions: This study was the first genomic screening of the GHS-R1a gene in a population. It suggests that genetic variations in the GHS-R1a gene are not the main regulators of IGF-I levels. However, the variants may be associated with IGFBP-1 concentrations and insulin metabolism.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 VARTIAINEN (Johanna)`
A11	`02`	`1`		`@1 PÖYKKÖ (Seppo M.)`
A11	`03`	`1`		`@1 RÄISÄNEN (Tuija)`
A11	`04`	`1`		`@1 KESÄNIEMI (Y. Antero)`
A11	`05`	`1`		`@1 UKKOLA (Olavi)`
A14	`01`			`@1 Department of Internal Medicine and Biorenter Oulu, University of Oulu, PO Box 5000 @2 90014 Oulu @3 FIN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 4 aut. @Z 5 aut.`
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C01	`01`		`ENG`	@0 Objectives and design: Ghrelin is a novel 28 amino acid peptide which is reported to have several endocrine and non-endocrine actions. It possesses strong growth hormone (GH)-releasing activity. which is mediated via the GH secretagogue receptor type la (GHS-R1a). We hypothesised that there might be functional sequential variations in the GHS-R1a gene affecting phenotypes linked to the GH/insulin-like growth factor-I (IGF-I)-axis. Methods: To test our hypothesis we chose patients from our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study with low (n = 96) and high (n= 96) IGF-I levels. sequenced their GHS-R1a gene exons and performed association studies. Results: We found five single-nucleotide polymorphisms (SNPs) which did not change the amino acid sequence. We were unable to detect associations between the SNPs and the IGF-I plasma concentrations, but instead we showed that SNP 171C > T was associated with the values of the area under the insulin curve (AUCIN) in an oral glucose tolerance test and with IGF-binding protein-1 (IGFBP-1) concentrations (P < 0.05). SNP 477G > A was associated with the low density lipoprotein and very low density lipoprotein cholesterol plasma levels and AUCIN values (P < 0.05). Conclusions: This study was the first genomic screening of the GHS-R1a gene in a population. It suggests that genetic variations in the GHS-R1a gene are not the main regulators of IGF-I levels. However, the variants may be associated with IGFBP-1 concentrations and insulin metabolism.
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Format Inist (serveur)

NO :	PASCAL 04-0282832 INIST
ET :	Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene
AU :	VARTIAINEN (Johanna); PÖYKKÖ (Seppo M.); RÄISÄNEN (Tuija); KESÄNIEMI (Y. Antero); UKKOLA (Olavi)
AF :	Department of Internal Medicine and Biorenter Oulu, University of Oulu, PO Box 5000/90014 Oulu/Finlande (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)
DT :	Publication en série; Niveau analytique
SO :	European journal of endocrinology; ISSN 0804-4643; Royaume-Uni; Da. 2004; Vol. 150; No. 4; Pp. 457-463; Bibl. 35 ref.
LA :	Anglais
EA :	Objectives and design: Ghrelin is a novel 28 amino acid peptide which is reported to have several endocrine and non-endocrine actions. It possesses strong growth hormone (GH)-releasing activity. which is mediated via the GH secretagogue receptor type la (GHS-R1a). We hypothesised that there might be functional sequential variations in the GHS-R1a gene affecting phenotypes linked to the GH/insulin-like growth factor-I (IGF-I)-axis. Methods: To test our hypothesis we chose patients from our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study with low (n = 96) and high (n= 96) IGF-I levels. sequenced their GHS-R1a gene exons and performed association studies. Results: We found five single-nucleotide polymorphisms (SNPs) which did not change the amino acid sequence. We were unable to detect associations between the SNPs and the IGF-I plasma concentrations, but instead we showed that SNP 171C > T was associated with the values of the area under the insulin curve (AUCIN) in an oral glucose tolerance test and with IGF-binding protein-1 (IGFBP-1) concentrations (P < 0.05). SNP 477G > A was associated with the low density lipoprotein and very low density lipoprotein cholesterol plasma levels and AUCIN values (P < 0.05). Conclusions: This study was the first genomic screening of the GHS-R1a gene in a population. It suggests that genetic variations in the GHS-R1a gene are not the main regulators of IGF-I levels. However, the variants may be associated with IGFBP-1 concentrations and insulin metabolism.
CC :	002A28; 002B21
FD :	STH; Séquence nucléotide; Séquençage; Ghréline; Récepteur biologique; Récepteur hormonal; Gène; Génétique; Endocrinologie
FG :	Hormone adénohypophysaire
ED :	Somatotropin hormone; Nucleotide sequence; Sequencing; Ghrelin; Biological receptor; Hormonal receptor; Gene; Genetics; Endocrinology
EG :	Adenohypophyseal hormone
SD :	STH; Secuencia nucleótido; Sequencing; Grelina; Receptor biológico; Receptor hormonal; Gen; Genética; Endocrinología
LO :	INIST-5321.354000110001230080
ID :	04-0282832

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Pascal:04-0282832

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objectives and design: Ghrelin is a novel 28 amino acid peptide which is reported to have several endocrine and non-endocrine actions. It possesses strong growth hormone (GH)-releasing activity. which is mediated via the GH secretagogue receptor type la (GHS-R1a). We hypothesised that there might be functional sequential variations in the GHS-R1a gene affecting phenotypes linked to the GH/insulin-like growth factor-I (IGF-I)-axis. Methods: To test our hypothesis we chose patients from our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study with low (n = 96) and high (n= 96) IGF-I levels. sequenced their GHS-R1a gene exons and performed association studies. Results: We found five single-nucleotide polymorphisms (SNPs) which did not change the amino acid sequence. We were unable to detect associations between the SNPs and the IGF-I plasma concentrations, but instead we showed that SNP 171C > T was associated with the values of the area under the insulin curve (AUCIN) in an oral glucose tolerance test and with IGF-binding protein-1 (IGFBP-1) concentrations (P < 0.05). SNP 477G > A was associated with the low density lipoprotein and very low density lipoprotein cholesterol plasma levels and AUCIN values (P < 0.05). Conclusions: This study was the first genomic screening of the GHS-R1a gene in a population. It suggests that genetic variations in the GHS-R1a gene are not the main regulators of IGF-I levels. However, the variants may be associated with IGFBP-1 concentrations and insulin metabolism.</div>
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<fC01 i1="01" l="ENG"><s0>Objectives and design: Ghrelin is a novel 28 amino acid peptide which is reported to have several endocrine and non-endocrine actions. It possesses strong growth hormone (GH)-releasing activity. which is mediated via the GH secretagogue receptor type la (GHS-R1a). We hypothesised that there might be functional sequential variations in the GHS-R1a gene affecting phenotypes linked to the GH/insulin-like growth factor-I (IGF-I)-axis. Methods: To test our hypothesis we chose patients from our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study with low (n = 96) and high (n= 96) IGF-I levels. sequenced their GHS-R1a gene exons and performed association studies. Results: We found five single-nucleotide polymorphisms (SNPs) which did not change the amino acid sequence. We were unable to detect associations between the SNPs and the IGF-I plasma concentrations, but instead we showed that SNP 171C > T was associated with the values of the area under the insulin curve (AUCIN) in an oral glucose tolerance test and with IGF-binding protein-1 (IGFBP-1) concentrations (P < 0.05). SNP 477G > A was associated with the low density lipoprotein and very low density lipoprotein cholesterol plasma levels and AUCIN values (P < 0.05). Conclusions: This study was the first genomic screening of the GHS-R1a gene in a population. It suggests that genetic variations in the GHS-R1a gene are not the main regulators of IGF-I levels. However, the variants may be associated with IGFBP-1 concentrations and insulin metabolism.</s0>
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</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Sequencing</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Ghréline</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Ghrelin</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Grelina</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Récepteur biologique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Biological receptor</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Receptor biológico</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Récepteur hormonal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Hormonal receptor</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Receptor hormonal</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Gène</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Gene</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Gen</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Génétique</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Genetics</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Genética</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Endocrinologie</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Endocrinology</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Endocrinología</s0>
<s5>12</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Hormone adénohypophysaire</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Adenohypophyseal hormone</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Hormona adenohipofisaria</s0>
<s5>37</s5>
</fC07>
<fN21><s1>173</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 04-0282832 INIST</NO>
<ET>Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene</ET>
<AU>VARTIAINEN (Johanna); PÖYKKÖ (Seppo M.); RÄISÄNEN (Tuija); KESÄNIEMI (Y. Antero); UKKOLA (Olavi)</AU>
<AF>Department of Internal Medicine and Biorenter Oulu, University of Oulu, PO Box 5000/90014 Oulu/Finlande (1 aut., 2 aut., 3 aut., 4 aut., 5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>European journal of endocrinology; ISSN 0804-4643; Royaume-Uni; Da. 2004; Vol. 150; No. 4; Pp. 457-463; Bibl. 35 ref.</SO>
<LA>Anglais</LA>
<EA>Objectives and design: Ghrelin is a novel 28 amino acid peptide which is reported to have several endocrine and non-endocrine actions. It possesses strong growth hormone (GH)-releasing activity. which is mediated via the GH secretagogue receptor type la (GHS-R1a). We hypothesised that there might be functional sequential variations in the GHS-R1a gene affecting phenotypes linked to the GH/insulin-like growth factor-I (IGF-I)-axis. Methods: To test our hypothesis we chose patients from our OPERA (Oulu Project Elucidating Risk of Atherosclerosis) study with low (n = 96) and high (n= 96) IGF-I levels. sequenced their GHS-R1a gene exons and performed association studies. Results: We found five single-nucleotide polymorphisms (SNPs) which did not change the amino acid sequence. We were unable to detect associations between the SNPs and the IGF-I plasma concentrations, but instead we showed that SNP 171C > T was associated with the values of the area under the insulin curve (AUCIN) in an oral glucose tolerance test and with IGF-binding protein-1 (IGFBP-1) concentrations (P < 0.05). SNP 477G > A was associated with the low density lipoprotein and very low density lipoprotein cholesterol plasma levels and AUCIN values (P < 0.05). Conclusions: This study was the first genomic screening of the GHS-R1a gene in a population. It suggests that genetic variations in the GHS-R1a gene are not the main regulators of IGF-I levels. However, the variants may be associated with IGFBP-1 concentrations and insulin metabolism.</EA>
<CC>002A28; 002B21</CC>
<FD>STH; Séquence nucléotide; Séquençage; Ghréline; Récepteur biologique; Récepteur hormonal; Gène; Génétique; Endocrinologie</FD>
<FG>Hormone adénohypophysaire</FG>
<ED>Somatotropin hormone; Nucleotide sequence; Sequencing; Ghrelin; Biological receptor; Hormonal receptor; Gene; Genetics; Endocrinology</ED>
<EG>Adenohypophyseal hormone</EG>
<SD>STH; Secuencia nucleótido; Sequencing; Grelina; Receptor biológico; Receptor hormonal; Gen; Genética; Endocrinología</SD>
<LO>INIST-5321.354000110001230080</LO>
<ID>04-0282832</ID>
</server>
</inist>
</record>

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Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene

Sequencing analysis of the ghrelin receptor (growth hormone secretagogue receptor type 1a) gene

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