Design of the Omapatrilat in Persons with Enhanced Risk of atherosclerotic events (OPERA) trial
Identifieur interne : 002217 ( Main/Merge ); précédent : 002216; suivant : 002218Design of the Omapatrilat in Persons with Enhanced Risk of atherosclerotic events (OPERA) trial
Auteurs : John B. Kostis [États-Unis] ; Stuart Cobbe [Royaume-Uni] ; Colin Johnston [Australie] ; Ian Ford [Royaume-Uni] ; Michael Murphy [Irlande (pays)] ; Michael A. Weber [États-Unis] ; Henry R. Black [France] ; Pierre Francois Plouin [France] ; Daniel Levy [États-Unis] ; Guiseppe Mancia [Italie] ; Pierre Larochelle [Canada] ; Rainer E. Kolloch [Allemagne] ; Michael Alderman [États-Unis] ; Luis Miguel Ruilope [Espagne] ; Björn Dahlöf [Suède] ; John M. Flack [États-Unis] ; Robert Wolf [États-Unis]Source :
- American journal of hypertension [ 0895-7061 ] ; 2002.
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Abstract
The Omapatrilat in Persons with Enhanced Risk of Atherosclerotic events (OPERA) trial is a large clinical trial of omapatrilat, a vasopeptidase inhibitor, in patients with stage 1 isolated systolic hypertension (ISH). OPERA is the first study to examine whether effective antihypertensive treatment can provide survival and clinical end point benefits in older persons with this common condition. This 5-year multinational, randomized, double-blind, parallel-group, placebo-controlled, forced-titration study will be conducted in approximately 12,600 subjects randomized by approximately 1100 study centers worldwide over a recruitment period of approximately 2 years. The primary objective of OPERA is to determine whether treatment with once-daily omapatrilat (target dose 40 mg) will reduce cardiovascular (CV) morbidity and mortality in older (≥65 years) men and women with enhanced risk for atherosclerotic events due to stage I ISH plus other risk factors for which currently there is no evidence-based requirement for treatment. Blood pressure inclusion criteria are systolic blood pressure (SBP) 140 to 159 mm Hg (SBP 125 to 139 mm Hg in diabetic individuals) and diastolic blood pressure (DBP) <90 mm Hg. The primary end point is defined as the composite of fatal/nonfatal stroke, fatal/nonfatal myocardial infarction. fatal/nonfatal heart failure, and other CV mortality. Secondary end points include the individual components of the primary end point, CV mortality, and major cardiovascular end points, as well as effects on cognitive function and initiation of treatment for diabetes. Additional analyses will be conducted in men and women, in diabetic patients, in different risk classes and according to prior evidence of vascular disease.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Design of the Omapatrilat in Persons with Enhanced Risk of atherosclerotic events (OPERA) trial</title><author><name sortKey="Kostis, John B" sort="Kostis, John B" uniqKey="Kostis J" first="John B." last="Kostis">John B. Kostis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick, New Jersey</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Cobbe, Stuart" sort="Cobbe, Stuart" uniqKey="Cobbe S" first="Stuart" last="Cobbe">Stuart Cobbe</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>University of Glasgow</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université de Glasgow</orgName></affiliation></author><author><name sortKey="Johnston, Colin" sort="Johnston, Colin" uniqKey="Johnston C" first="Colin" last="Johnston">Colin Johnston</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Baker Medical Research Institute</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker Medical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>University of Glasgow</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université de Glasgow</orgName></affiliation></author><author><name sortKey="Murphy, Michael" sort="Murphy, Michael" uniqKey="Murphy M" first="Michael" last="Murphy">Michael Murphy</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cork University Hospital</s1><s2>Cork</s2><s3>IRL</s3><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Cork University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Michael A" sort="Weber, Michael A" uniqKey="Weber M" first="Michael A." last="Weber">Michael A. 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Gerardo dei Tintori</s1><s2>Monza</s2><s3>ITA</s3><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Ospedale S. Gerardo dei Tintori</wicri:noRegion></affiliation></author><author><name sortKey="Larochelle, Pierre" sort="Larochelle, Pierre" uniqKey="Larochelle P" first="Pierre" last="Larochelle">Pierre Larochelle</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institut de Recherces Cliniques de Montreal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Kolloch, Rainer E" sort="Kolloch, Rainer E" uniqKey="Kolloch R" first="Rainer E." last="Kolloch">Rainer E. Kolloch</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Wilhelms-Universitat</s1><s2>Bleiefeld</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bleiefeld</wicri:noRegion><wicri:noRegion>Wilhelms-Universitat</wicri:noRegion><wicri:noRegion>Wilhelms-Universitat</wicri:noRegion></affiliation></author><author><name sortKey="Alderman, Michael" sort="Alderman, Michael" uniqKey="Alderman M" first="Michael" last="Alderman">Michael Alderman</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Albert Einstein College of Medicine</s1><s2>Bronx, New York</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ruilope, Luis Miguel" sort="Ruilope, Luis Miguel" uniqKey="Ruilope L" first="Luis Miguel" last="Ruilope">Luis Miguel Ruilope</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Hospital Doce De Octubre</s1><s2>Madrid</s2><s3>ESP</s3><sZ>14 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital Doce De Octubre</wicri:noRegion></affiliation></author><author><name sortKey="Dahlof, Bjorn" sort="Dahlof, Bjorn" uniqKey="Dahlof B" first="Björn" last="Dahlöf">Björn Dahlöf</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Ostra University Hospital</s1><s2>Goteborg</s2><s3>SWE</s3><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Ostra University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Flack, John M" sort="Flack, John M" uniqKey="Flack J" first="John M." last="Flack">John M. Flack</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Harper Hospital</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wolf, Robert" sort="Wolf, Robert" uniqKey="Wolf R" first="Robert" last="Wolf">Robert Wolf</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Bristol-Myers Squibb</s1><s2>Princeton, New Jersey</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">02-0201829</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 02-0201829 INIST</idno><idno type="RBID">Pascal:02-0201829</idno><idno type="wicri:Area/PascalFrancis/Corpus">000598</idno><idno type="wicri:Area/PascalFrancis/Curation">000084</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000526</idno><idno type="wicri:doubleKey">0895-7061:2002:Kostis J:design:of:the</idno><idno type="wicri:Area/Main/Merge">002217</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Design of the Omapatrilat in Persons with Enhanced Risk of atherosclerotic events (OPERA) trial</title><author><name sortKey="Kostis, John B" sort="Kostis, John B" uniqKey="Kostis J" first="John B." last="Kostis">John B. Kostis</name><affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School</s1><s2>New Brunswick, New Jersey</s2><s3>USA</s3><sZ>1 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author><author><name sortKey="Cobbe, Stuart" sort="Cobbe, Stuart" uniqKey="Cobbe S" first="Stuart" last="Cobbe">Stuart Cobbe</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>University of Glasgow</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université de Glasgow</orgName></affiliation></author><author><name sortKey="Johnston, Colin" sort="Johnston, Colin" uniqKey="Johnston C" first="Colin" last="Johnston">Colin Johnston</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Baker Medical Research Institute</s1><s2>Melbourne</s2><s3>AUS</s3><sZ>3 aut.</sZ></inist:fA14><country>Australie</country><wicri:noRegion>Baker Medical Research Institute</wicri:noRegion></affiliation></author><author><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>University of Glasgow</s1><s2>Glasgow, Scotland</s2><s3>GBR</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Glasgow</settlement><region type="country">Écosse</region></placeName><orgName type="university">Université de Glasgow</orgName></affiliation></author><author><name sortKey="Murphy, Michael" sort="Murphy, Michael" uniqKey="Murphy M" first="Michael" last="Murphy">Michael Murphy</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Cork University Hospital</s1><s2>Cork</s2><s3>IRL</s3><sZ>5 aut.</sZ></inist:fA14><country>Irlande (pays)</country><wicri:noRegion>Cork University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Michael A" sort="Weber, Michael A" uniqKey="Weber M" first="Michael A." last="Weber">Michael A. Weber</name><affiliation wicri:level="2"><inist:fA14 i1="05"><s1>Bookdale Hospital Medical Center</s1><s2>Brooklyn, New York</s2><s3>USA</s3><sZ>6 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Black, Henry R" sort="Black, Henry R" uniqKey="Black H" first="Henry R." last="Black">Henry R. Black</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Rush-Presbyterian-St. Luke's Medical Center</s1><s2>Chicago, Illinois</s2><s3>FRA</s3><sZ>7 aut.</sZ></inist:fA14><country>France</country><wicri:noRegion>Illinois</wicri:noRegion><wicri:noRegion>Rush-Presbyterian-St. Luke's Medical Center</wicri:noRegion><wicri:noRegion>Rush-Presbyterian-St. Luke's Medical Center</wicri:noRegion></affiliation></author><author><name sortKey="Plouin, Pierre Francois" sort="Plouin, Pierre Francois" uniqKey="Plouin P" first="Pierre Francois" last="Plouin">Pierre Francois Plouin</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Hôpital European Georges Pompidou</s1><s2>Paris</s2><s3>FRA</s3><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><affiliation wicri:level="2"><inist:fA14 i1="08"><s1>Framingham Heart Study Institution</s1><s2>Framingham, Massachusetts</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Mancia, Guiseppe" sort="Mancia, Guiseppe" uniqKey="Mancia G" first="Guiseppe" last="Mancia">Guiseppe Mancia</name><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Ospedale S. Gerardo dei Tintori</s1><s2>Monza</s2><s3>ITA</s3><sZ>10 aut.</sZ></inist:fA14><country>Italie</country><wicri:noRegion>Ospedale S. Gerardo dei Tintori</wicri:noRegion></affiliation></author><author><name sortKey="Larochelle, Pierre" sort="Larochelle, Pierre" uniqKey="Larochelle P" first="Pierre" last="Larochelle">Pierre Larochelle</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>Institut de Recherces Cliniques de Montreal</s1><s2>Montreal</s2><s3>CAN</s3><sZ>11 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Kolloch, Rainer E" sort="Kolloch, Rainer E" uniqKey="Kolloch R" first="Rainer E." last="Kolloch">Rainer E. Kolloch</name><affiliation wicri:level="1"><inist:fA14 i1="11"><s1>Wilhelms-Universitat</s1><s2>Bleiefeld</s2><s3>DEU</s3><sZ>12 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Bleiefeld</wicri:noRegion><wicri:noRegion>Wilhelms-Universitat</wicri:noRegion><wicri:noRegion>Wilhelms-Universitat</wicri:noRegion></affiliation></author><author><name sortKey="Alderman, Michael" sort="Alderman, Michael" uniqKey="Alderman M" first="Michael" last="Alderman">Michael Alderman</name><affiliation wicri:level="2"><inist:fA14 i1="12"><s1>Albert Einstein College of Medicine</s1><s2>Bronx, New York</s2><s3>USA</s3><sZ>13 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ruilope, Luis Miguel" sort="Ruilope, Luis Miguel" uniqKey="Ruilope L" first="Luis Miguel" last="Ruilope">Luis Miguel Ruilope</name><affiliation wicri:level="1"><inist:fA14 i1="13"><s1>Hospital Doce De Octubre</s1><s2>Madrid</s2><s3>ESP</s3><sZ>14 aut.</sZ></inist:fA14><country>Espagne</country><wicri:noRegion>Hospital Doce De Octubre</wicri:noRegion></affiliation></author><author><name sortKey="Dahlof, Bjorn" sort="Dahlof, Bjorn" uniqKey="Dahlof B" first="Björn" last="Dahlöf">Björn Dahlöf</name><affiliation wicri:level="1"><inist:fA14 i1="14"><s1>Ostra University Hospital</s1><s2>Goteborg</s2><s3>SWE</s3><sZ>15 aut.</sZ></inist:fA14><country>Suède</country><wicri:noRegion>Ostra University Hospital</wicri:noRegion></affiliation></author><author><name sortKey="Flack, John M" sort="Flack, John M" uniqKey="Flack J" first="John M." last="Flack">John M. Flack</name><affiliation wicri:level="2"><inist:fA14 i1="15"><s1>Harper Hospital</s1><s2>Detroit, Michigan</s2><s3>USA</s3><sZ>16 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Wolf, Robert" sort="Wolf, Robert" uniqKey="Wolf R" first="Robert" last="Wolf">Robert Wolf</name><affiliation wicri:level="2"><inist:fA14 i1="16"><s1>Bristol-Myers Squibb</s1><s2>Princeton, New Jersey</s2><s3>USA</s3><sZ>17 aut.</sZ></inist:fA14><country>États-Unis</country><placeName><region type="state">New Jersey</region></placeName></affiliation></author></analytic><series><title level="j" type="main">American journal of hypertension</title><title level="j" type="abbreviated">Am. j. hypertens.</title><idno type="ISSN">0895-7061</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">American journal of hypertension</title><title level="j" type="abbreviated">Am. j. hypertens.</title><idno type="ISSN">0895-7061</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antihypertensive agent</term><term>Atherosclerosis</term><term>Chemotherapy</term><term>Human</term><term>Hypertension</term><term>Omapatrilat</term><term>Prognosis</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Athérosclérose</term><term>Hypertension artérielle</term><term>Omapatrilate</term><term>Chimiothérapie</term><term>Traitement</term><term>Pronostic</term><term>Homme</term><term>Antihypertenseur</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The Omapatrilat in Persons with Enhanced Risk of Atherosclerotic events (OPERA) trial is a large clinical trial of omapatrilat, a vasopeptidase inhibitor, in patients with stage 1 isolated systolic hypertension (ISH). OPERA is the first study to examine whether effective antihypertensive treatment can provide survival and clinical end point benefits in older persons with this common condition. This 5-year multinational, randomized, double-blind, parallel-group, placebo-controlled, forced-titration study will be conducted in approximately 12,600 subjects randomized by approximately 1100 study centers worldwide over a recruitment period of approximately 2 years. The primary objective of OPERA is to determine whether treatment with once-daily omapatrilat (target dose 40 mg) will reduce cardiovascular (CV) morbidity and mortality in older (≥65 years) men and women with enhanced risk for atherosclerotic events due to stage I ISH plus other risk factors for which currently there is no evidence-based requirement for treatment. Blood pressure inclusion criteria are systolic blood pressure (SBP) 140 to 159 mm Hg (SBP 125 to 139 mm Hg in diabetic individuals) and diastolic blood pressure (DBP) <90 mm Hg. The primary end point is defined as the composite of fatal/nonfatal stroke, fatal/nonfatal myocardial infarction. fatal/nonfatal heart failure, and other CV mortality. Secondary end points include the individual components of the primary end point, CV mortality, and major cardiovascular end points, as well as effects on cognitive function and initiation of treatment for diabetes. Additional analyses will be conducted in men and women, in diabetic patients, in different risk classes and according to prior evidence of vascular disease.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Irlande (pays)</li><li>Italie</li><li>Royaume-Uni</li><li>Suède</li><li>États-Unis</li></country><region><li>Massachusetts</li><li>Michigan</li><li>New Jersey</li><li>Québec</li><li>Écosse</li><li>État de New York</li></region><settlement><li>Glasgow</li><li>Montréal</li><li>Paris</li></settlement><orgName><li>Université de Glasgow</li></orgName></list><tree><country name="États-Unis"><region name="New Jersey"><name sortKey="Kostis, John B" sort="Kostis, John B" uniqKey="Kostis J" first="John B." last="Kostis">John B. Kostis</name></region><name sortKey="Alderman, Michael" sort="Alderman, Michael" uniqKey="Alderman M" first="Michael" last="Alderman">Michael Alderman</name><name sortKey="Flack, John M" sort="Flack, John M" uniqKey="Flack J" first="John M." last="Flack">John M. Flack</name><name sortKey="Levy, Daniel" sort="Levy, Daniel" uniqKey="Levy D" first="Daniel" last="Levy">Daniel Levy</name><name sortKey="Weber, Michael A" sort="Weber, Michael A" uniqKey="Weber M" first="Michael A." last="Weber">Michael A. Weber</name><name sortKey="Wolf, Robert" sort="Wolf, Robert" uniqKey="Wolf R" first="Robert" last="Wolf">Robert Wolf</name></country><country name="Royaume-Uni"><region name="Écosse"><name sortKey="Cobbe, Stuart" sort="Cobbe, Stuart" uniqKey="Cobbe S" first="Stuart" last="Cobbe">Stuart Cobbe</name></region><name sortKey="Ford, Ian" sort="Ford, Ian" uniqKey="Ford I" first="Ian" last="Ford">Ian Ford</name></country><country name="Australie"><noRegion><name sortKey="Johnston, Colin" sort="Johnston, Colin" uniqKey="Johnston C" first="Colin" last="Johnston">Colin Johnston</name></noRegion></country><country name="Irlande (pays)"><noRegion><name sortKey="Murphy, Michael" sort="Murphy, Michael" uniqKey="Murphy M" first="Michael" last="Murphy">Michael Murphy</name></noRegion></country><country name="France"><noRegion><name sortKey="Black, Henry R" sort="Black, Henry R" uniqKey="Black H" first="Henry R." last="Black">Henry R. Black</name></noRegion><name sortKey="Plouin, Pierre Francois" sort="Plouin, Pierre Francois" uniqKey="Plouin P" first="Pierre Francois" last="Plouin">Pierre Francois Plouin</name></country><country name="Italie"><noRegion><name sortKey="Mancia, Guiseppe" sort="Mancia, Guiseppe" uniqKey="Mancia G" first="Guiseppe" last="Mancia">Guiseppe Mancia</name></noRegion></country><country name="Canada"><region name="Québec"><name sortKey="Larochelle, Pierre" sort="Larochelle, Pierre" uniqKey="Larochelle P" first="Pierre" last="Larochelle">Pierre Larochelle</name></region></country><country name="Allemagne"><noRegion><name sortKey="Kolloch, Rainer E" sort="Kolloch, Rainer E" uniqKey="Kolloch R" first="Rainer E." last="Kolloch">Rainer E. Kolloch</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Ruilope, Luis Miguel" sort="Ruilope, Luis Miguel" uniqKey="Ruilope L" first="Luis Miguel" last="Ruilope">Luis Miguel Ruilope</name></noRegion></country><country name="Suède"><noRegion><name sortKey="Dahlof, Bjorn" sort="Dahlof, Bjorn" uniqKey="Dahlof B" first="Björn" last="Dahlöf">Björn Dahlöf</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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