Serveur d'exploration sur l'opéra

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects

Identifieur interne : 001753 ( Main/Merge ); précédent : 001752; suivant : 001754

Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects

Auteurs : O. Ukkola [Finlande] ; Y. A. Kes Niemi [Finlande]

Source :

RBID : Pascal:07-0426249

Descripteurs français

English descriptors

Abstract

Objectives: Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension. Design: Blood pressure recordings and oral glucose tolerance test were performed in the hypertensive (n= 515) and control cohorts (n = 525) of our well-defined Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study. The prevalence of type II diabetes was 9% (n=93). The genotypes, insulin and glucose metabolism indexes and plasma ghrelin of the subjects were determined. Results: Pro7 allele frequencies were 5.9, 5.3 and 11.3% in the total cohort, in subjects without and with type II diabetes, respectively. The PreproNPY Pro7 carrier status was a significant risk factor for type II diabetes, and the effect remained significant after adjustment for age, sex, waist circumference and study group (odds ratio = 3.02, confidence interval: 1.67-5.44 and P<0.001). Pro7 carriers were more insulin resistant and showed lower ghrelin levels compared to non-carriers. Conclusions: The PreproNPY Pro7 allele is associated with an increased risk for type II diabetes. The risk seems to be associated with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels. Sponsorship: None.

Links toward previous steps (curation, corpus...)


Links to Exploration step

Pascal:07-0426249

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en" level="a">Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects</title>
<author>
<name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O." last="Ukkola">O. Ukkola</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter Oulu, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y. A." last="Kes Niemi">Y. A. Kes Niemi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter Oulu, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">INIST</idno>
<idno type="inist">07-0426249</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0426249 INIST</idno>
<idno type="RBID">Pascal:07-0426249</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000330</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000237</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000274</idno>
<idno type="wicri:doubleKey">0954-3007:2007:Ukkola O:leu:pro:polymorphism</idno>
<idno type="wicri:Area/Main/Merge">001753</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a">Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects</title>
<author>
<name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O." last="Ukkola">O. Ukkola</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter Oulu, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y. A." last="Kes Niemi">Y. A. Kes Niemi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter Oulu, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">European journal of clinical nutrition</title>
<title level="j" type="abbreviated">Eur. j. clin. nutr.</title>
<idno type="ISSN">0954-3007</idno>
<imprint>
<date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">European journal of clinical nutrition</title>
<title level="j" type="abbreviated">Eur. j. clin. nutr.</title>
<idno type="ISSN">0954-3007</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Association</term>
<term>Human</term>
<term>Middle age</term>
<term>Nutrition</term>
<term>Polymorphism</term>
<term>Risk</term>
<term>Risk factor</term>
<term>Type 2 diabetes</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Diabète type 2</term>
<term>Polymorphisme</term>
<term>Association</term>
<term>Facteur risque</term>
<term>Risque</term>
<term>Age mûr</term>
<term>Homme</term>
<term>Nutrition</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Association</term>
<term>Homme</term>
<term>Nutrition</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Objectives: Neuropeptide Y (NPY) plays a central in energy homeostasis and potentially in the development of obesity-related comorbidities, like type II diabetes. As the PreproNPY Leu7Pro polymorphism probably changes the intracellular processing of the synthesized preproNPY peptide, we assessed the hypothesis that PreproNPY Leu7Pro polymorphism is a risk factor for type II diabetes, impaired glucose tolerance and hypertension. Design: Blood pressure recordings and oral glucose tolerance test were performed in the hypertensive (n= 515) and control cohorts (n = 525) of our well-defined Oulu Project Elucidating Risk of Atherosclerosis (OPERA) study. The prevalence of type II diabetes was 9% (n=93). The genotypes, insulin and glucose metabolism indexes and plasma ghrelin of the subjects were determined. Results: Pro7 allele frequencies were 5.9, 5.3 and 11.3% in the total cohort, in subjects without and with type II diabetes, respectively. The PreproNPY Pro7 carrier status was a significant risk factor for type II diabetes, and the effect remained significant after adjustment for age, sex, waist circumference and study group (odds ratio = 3.02, confidence interval: 1.67-5.44 and P<0.001). Pro7 carriers were more insulin resistant and showed lower ghrelin levels compared to non-carriers. Conclusions: The PreproNPY Pro7 allele is associated with an increased risk for type II diabetes. The risk seems to be associated with a higher insulin resistance among Pro7 carriers whereas low ghrelin concentrations in Pro7 carriers are possibly a consequence of high insulin levels. Sponsorship: None.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Finlande</li>
</country>
</list>
<tree>
<country name="Finlande">
<noRegion>
<name sortKey="Ukkola, O" sort="Ukkola, O" uniqKey="Ukkola O" first="O." last="Ukkola">O. Ukkola</name>
</noRegion>
<name sortKey="Kes Niemi, Y A" sort="Kes Niemi, Y A" uniqKey="Kes Niemi Y" first="Y. A." last="Kes Niemi">Y. A. Kes Niemi</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/OperaV1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001753 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 001753 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Musique
   |area=    OperaV1
   |flux=    Main
   |étape=   Merge
   |type=    RBID
   |clé=     Pascal:07-0426249
   |texte=   Leu7Pro polymorphism of PreproNPY associated with an increased risk for type II diabetes in middle-aged subjects
}}

Wicri

This area was generated with Dilib version V0.6.21.
Data generation: Thu Apr 14 14:59:05 2016. Site generation: Thu Oct 8 06:48:41 2020