Serveur d'exploration sur l'opéra

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.

Identifieur interne : 004A26 ( Main/Exploration ); précédent : 004A25; suivant : 004A27

Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.

Auteurs : Stinne Ravn Greisen [Danemark] ; Holger Jon M Ller [Danemark] ; Kristian Stengaard-Pedersen [Danemark] ; Merete Lund Hetland [Danemark] ; Kim H Rslev-Petersen [Danemark] ; Peter Junker [Danemark] ; Mikkel Stergaard [Danemark] ; Malene Hvid [Danemark] ; Bent Deleuran [Danemark]

Source :

RBID : pubmed:25962601

Mots-clés :

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease where TNF-α is a central mediator of inflammation, and is cleaved from the cell surface by TACE/ADAM17. This metalloproteinase is also responsible for the release of soluble (s) CD163. Soluble CD163 reflects macrophage activation. In RA, sCD163 has been suggested as a marker of disease activity and progression. Our aim is to investigate sCD163 levels in early RA patients.


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en">Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.</title>
<author>
<name sortKey="Greisen, Stinne Ravn" sort="Greisen, Stinne Ravn" uniqKey="Greisen S" first="Stinne Ravn" last="Greisen">Stinne Ravn Greisen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biomedicine, Aarhus University; and Department of Rheumatology, Aarhus University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Biomedicine, Aarhus University; and Department of Rheumatology, Aarhus University Hospital</wicri:regionArea>
<wicri:noRegion>Aarhus University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="M Ller, Holger Jon" sort="M Ller, Holger Jon" uniqKey="M Ller H" first="Holger Jon" last="M Ller">Holger Jon M Ller</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Biochemistry, Aarhus University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Aarhus University Hospital</wicri:regionArea>
<wicri:noRegion>Aarhus University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Aarhus University Hospital</wicri:regionArea>
<wicri:noRegion>Aarhus University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name>
<affiliation wicri:level="1">
<nlm:affiliation>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
<affiliation wicri:level="1">
<nlm:affiliation>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark</wicri:regionArea>
<wicri:noRegion>and University of Southern Denmark</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Odense University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Odense University Hospital</wicri:regionArea>
<wicri:noRegion>Odense University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University</wicri:regionArea>
<wicri:noRegion>Aarhus University</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University</wicri:regionArea>
<wicri:noRegion>Aarhus University</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">PubMed</idno>
<date when="????">
<PubDate>
<MedlineDate>2015 Jul-Aug</MedlineDate>
</PubDate>
</date>
<idno type="RBID">pubmed:25962601</idno>
<idno type="pmid">25962601</idno>
<idno type="wicri:Area/PubMed/Corpus">000080</idno>
<idno type="wicri:Area/PubMed/Curation">000080</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000851</idno>
<idno type="wicri:Area/Ncbi/Merge">000D54</idno>
<idno type="wicri:Area/Ncbi/Curation">000D54</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000D54</idno>
<idno type="wicri:doubleKey">0392-856X::Greisen S:macrophage:activity:assessed</idno>
<idno type="wicri:Area/Main/Merge">004C02</idno>
<idno type="wicri:Area/Main/Curation">004A26</idno>
<idno type="wicri:Area/Main/Exploration">004A26</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en">Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.</title>
<author>
<name sortKey="Greisen, Stinne Ravn" sort="Greisen, Stinne Ravn" uniqKey="Greisen S" first="Stinne Ravn" last="Greisen">Stinne Ravn Greisen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biomedicine, Aarhus University; and Department of Rheumatology, Aarhus University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Biomedicine, Aarhus University; and Department of Rheumatology, Aarhus University Hospital</wicri:regionArea>
<wicri:noRegion>Aarhus University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="M Ller, Holger Jon" sort="M Ller, Holger Jon" uniqKey="M Ller H" first="Holger Jon" last="M Ller">Holger Jon M Ller</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Clinical Biochemistry, Aarhus University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Clinical Biochemistry, Aarhus University Hospital</wicri:regionArea>
<wicri:noRegion>Aarhus University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Aarhus University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Aarhus University Hospital</wicri:regionArea>
<wicri:noRegion>Aarhus University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name>
<affiliation wicri:level="1">
<nlm:affiliation>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
<affiliation wicri:level="1">
<nlm:affiliation>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>King Christian 10th Hospital for the Rheumatic Diseases, and University of Southern Denmark</wicri:regionArea>
<wicri:noRegion>and University of Southern Denmark</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Rheumatology, Odense University Hospital, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, Odense University Hospital</wicri:regionArea>
<wicri:noRegion>Odense University Hospital</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name>
<affiliation wicri:level="1">
<nlm:affiliation>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Copenhagen Centre for Arthritis Research, Centre for Rheumatology and Spine Diseases, Glostrup Hospital; and Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen</wicri:regionArea>
<wicri:noRegion>University of Copenhagen</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Biomedicine, and Department of Clinical Medicine, Aarhus University</wicri:regionArea>
<wicri:noRegion>Aarhus University</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name>
<affiliation wicri:level="1">
<nlm:affiliation>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Biomedicine, Aarhus University; Department of Rheumatology, Aarhus University Hospital; and Department of Clinical Medicine, Aarhus University</wicri:regionArea>
<wicri:noRegion>Aarhus University</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j">Clinical and experimental rheumatology</title>
<idno type="ISSN">0392-856X</idno>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adalimumab</term>
<term>Antibodies, Monoclonal, Humanized (administration & dosage)</term>
<term>Antigens, CD (blood)</term>
<term>Antigens, Differentiation, Myelomonocytic (blood)</term>
<term>Antirheumatic Agents (administration & dosage)</term>
<term>Arthritis, Rheumatoid (diagnosis)</term>
<term>Arthritis, Rheumatoid (drug therapy)</term>
<term>Arthritis, Rheumatoid (immunology)</term>
<term>Arthritis, Rheumatoid (physiopathology)</term>
<term>Biomarkers (blood)</term>
<term>Disease Progression</term>
<term>Early Diagnosis</term>
<term>Female</term>
<term>Humans</term>
<term>Macrophage Activation (drug effects)</term>
<term>Macrophage Activation (immunology)</term>
<term>Male</term>
<term>Methotrexate (administration & dosage)</term>
<term>Middle Aged</term>
<term>Patient Acuity</term>
<term>Predictive Value of Tests</term>
<term>Receptors, Cell Surface (blood)</term>
<term>Receptors, Scavenger (blood)</term>
<term>Tumor Necrosis Factor-alpha (blood)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en">
<term>Antibodies, Monoclonal, Humanized</term>
<term>Antirheumatic Agents</term>
<term>Methotrexate</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en">
<term>Antigens, CD</term>
<term>Antigens, Differentiation, Myelomonocytic</term>
<term>Biomarkers</term>
<term>Receptors, Cell Surface</term>
<term>Receptors, Scavenger</term>
<term>Tumor Necrosis Factor-alpha</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en">
<term>Adalimumab</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en">
<term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en">
<term>Macrophage Activation</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en">
<term>Arthritis, Rheumatoid</term>
<term>Macrophage Activation</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en">
<term>Arthritis, Rheumatoid</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Disease Progression</term>
<term>Early Diagnosis</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Patient Acuity</term>
<term>Predictive Value of Tests</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Rheumatoid arthritis (RA) is a chronic autoimmune disease where TNF-α is a central mediator of inflammation, and is cleaved from the cell surface by TACE/ADAM17. This metalloproteinase is also responsible for the release of soluble (s) CD163. Soluble CD163 reflects macrophage activation. In RA, sCD163 has been suggested as a marker of disease activity and progression. Our aim is to investigate sCD163 levels in early RA patients.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Danemark</li>
</country>
</list>
<tree>
<country name="Danemark">
<noRegion>
<name sortKey="Greisen, Stinne Ravn" sort="Greisen, Stinne Ravn" uniqKey="Greisen S" first="Stinne Ravn" last="Greisen">Stinne Ravn Greisen</name>
</noRegion>
<name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name>
<name sortKey="Deleuran, Bent" sort="Deleuran, Bent" uniqKey="Deleuran B" first="Bent" last="Deleuran">Bent Deleuran</name>
<name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
<name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name>
<name sortKey="Hvid, Malene" sort="Hvid, Malene" uniqKey="Hvid M" first="Malene" last="Hvid">Malene Hvid</name>
<name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
<name sortKey="M Ller, Holger Jon" sort="M Ller, Holger Jon" uniqKey="M Ller H" first="Holger Jon" last="M Ller">Holger Jon M Ller</name>
<name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/corpus/OperaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004A26 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Musique
   |area=    OperaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:25962601
   |texte=   Macrophage activity assessed by soluble CD163 in early rheumatoid arthritis: association with disease activity but different response patterns to synthetic and biologic DMARDs.
}}

Wicri

This area was generated with Dilib version V0.6.21.
Data generation: Thu Apr 14 14:59:05 2016. Site generation: Wed Aug 16 22:49:51 2017