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Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients.

Identifieur interne : 001E10 ( Main/Exploration ); précédent : 001E09; suivant : 001E11

Methylenetetrahydrofolate reductase and angiotensin converting enzyme gene polymorphisms in two genetically and diagnostically distinct cohort of Alzheimer patients.

Auteurs : Davide Seripa [Italie] ; Gloria Dal Forno ; Maria G. Matera ; Carolina Gravina ; Maurizio Margaglione ; Mark T. Palermo ; David R. Wekstein ; Piero Antuono ; Daron G. Davis ; Antonio Daniele ; Carlo Masullo ; Alessandra Bizzarro ; Massimo Gennarelli ; Vito M. Fazio

Source :

RBID : pubmed:12928053

Mots-clés :

Abstract

The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. In this study, we investigated the common MTHFR C677-->T and ACE insertion/deletion (I/D) gene polymorphisms as risk factors for AD in two genetically and diagnostically distinct cohort of Alzheimer's patients. We analyzed a neuropathologically confirmed American cohort of 124 AD patients and 97 elderly controls, and a clinically diagnosed Italian cohort of 126 probable AD cases, 106 elderly controls, and a community-based sample of 1232 subjects aged under 65 years. No difference was found in polymorphism distribution between cases and controls in both study cohorts. We also tested a possible association between the polymorphisms investigated. No interaction was found between the MTHFR and ACE alleles. Moreover, no association was found for the ACE and MTHFR polymorphisms with age at onset, disease duration and MMSE score at observation. Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD.


Affiliations:


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Le document en format XML

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<term>Age of Onset</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Aging (genetics)</term>
<term>Alzheimer Disease (classification)</term>
<term>Alzheimer Disease (diagnosis)</term>
<term>Alzheimer Disease (enzymology)</term>
<term>Alzheimer Disease (ethnology)</term>
<term>Alzheimer Disease (genetics)</term>
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<term>Genetic Linkage</term>
<term>Genetic Predisposition to Disease</term>
<term>Humans</term>
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<term>Methylenetetrahydrofolate Reductase (NADPH2)</term>
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<term>Alzheimer Disease</term>
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<term>Genetic Predisposition to Disease</term>
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<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
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<front>
<div type="abstract" xml:lang="en">The role of methylenetetrahydrofolate reductase (MTHFR) and angiotensin converting enzyme (ACE) gene polymorphisms as risk factors for the occurrence of Alzheimer's disease (AD) is still controversial. In this study, we investigated the common MTHFR C677-->T and ACE insertion/deletion (I/D) gene polymorphisms as risk factors for AD in two genetically and diagnostically distinct cohort of Alzheimer's patients. We analyzed a neuropathologically confirmed American cohort of 124 AD patients and 97 elderly controls, and a clinically diagnosed Italian cohort of 126 probable AD cases, 106 elderly controls, and a community-based sample of 1232 subjects aged under 65 years. No difference was found in polymorphism distribution between cases and controls in both study cohorts. We also tested a possible association between the polymorphisms investigated. No interaction was found between the MTHFR and ACE alleles. Moreover, no association was found for the ACE and MTHFR polymorphisms with age at onset, disease duration and MMSE score at observation. Thus, in our study, MTHFR C677-->T and ACE I/D polymorphisms do not appear to confer an added risk for AD.</div>
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<name sortKey="Seripa, Davide" sort="Seripa, Davide" uniqKey="Seripa D" first="Davide" last="Seripa">Davide Seripa</name>
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