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Cultured neurons coupled to microelectrode arrays: circuit models, simulations and experimental data.

Identifieur interne : 001C27 ( Main/Exploration ); précédent : 001C26; suivant : 001C28

Cultured neurons coupled to microelectrode arrays: circuit models, simulations and experimental data.

Auteurs : Sergio Martinoia [Italie] ; Paolo Massobrio ; Marco Bove ; Giuseppe Massobrio

Source :

RBID : pubmed:15132514

English descriptors

Abstract

The purpose of this paper is to characterize the neuron-microelectrode junction, based on the equivalent electric-circuit approach. As a result, recording of action potentials can be simulated with a general-purpose circuit simulation program such as HSPICE. The response of the microelectrode was analyzed as a function of parameters such as sealing resistance and adhesion conditions. The models of the neuron and microelectrode implemented in HSPICE were first described. These models were used to simulate the behavior of the junction between a patch of neuronal membrane (described by the compartmental model) and a microelectrode.

DOI: 10.1109/TBME.2004.826607
PubMed: 15132514


Affiliations:


Links toward previous steps (curation, corpus...)


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<term>Electrophysiology (methods)</term>
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