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IGF-I concentrations are positively associated with carotid artery atherosclerosis in women

Identifieur interne : 001B57 ( Main/Exploration ); précédent : 001B56; suivant : 001B58

IGF-I concentrations are positively associated with carotid artery atherosclerosis in women

Auteurs : Mirella Hietaniemi [Finlande] ; Seppo M. Pöykkö [Finlande] ; Olavi Ukkola [Finlande] ; Markku P Iv Nsalo [Finlande] ; Y. Antero Kes Niemi [Finlande]

Source :

Annals of medicine : (Helsinki) [ 0785-3890 ] ; 2005.

RBID : Pascal:05-0414955

Descripteurs français

Pascal (Inist)
- Athérosclérose, Facteur croissance IGF1, Concentration, Association, Carotide, Femme, Femelle, Adulte, Appareil circulatoire pathologie, Paroi vasculaire, Intima, Epaisseur, Médecine.
Wicri :
- topic : Association, Femme, Adulte, Médecine.

English descriptors

KwdEn :
- Adult, Association, Atherosclerosis, Atherosclerosis (blood), Atherosclerosis (genetics), Atherosclerosis (pathology), Cardiovascular Diseases (blood), Cardiovascular Diseases (genetics), Cardiovascular Diseases (pathology), Cardiovascular disease, Carotid, Carotid Arteries (pathology), Carotid Artery Diseases (blood), Carotid Artery Diseases (genetics), Carotid Artery Diseases (pathology), Concentration, Female, Growth Substances (genetics), Humans, Insulin like growth factor 1, Insulin-Like Growth Factor I (analysis), Insulin-Like Growth Factor I (metabolism), Intima, Male, Medicine, Middle Aged, Polymorphism, Genetic, Risk Factors, Sex Factors, Thickness, Tunica Intima (pathology), Tunica Media (pathology), Vascular wall, Woman.
MESH :
- chemical , analysis : Insulin-Like Growth Factor I.
- chemical , genetics : Growth Substances.
- blood : Atherosclerosis, Cardiovascular Diseases, Carotid Artery Diseases.
- genetics : Atherosclerosis, Cardiovascular Diseases, Carotid Artery Diseases.
- chemical , metabolism : Insulin-Like Growth Factor I.
- pathology : Atherosclerosis, Cardiovascular Diseases, Carotid Arteries, Carotid Artery Diseases, Tunica Intima, Tunica Media.
- Female, Humans, Male, Middle Aged, Polymorphism, Genetic, Risk Factors, Sex Factors.

Abstract

BACKGROUND. Alterations in the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis are associated with increased cardiovascular morbidity and mortality, but previous studies have yielded conflicting results. In addition, the T1169A polymorphism in the GH1 gene has been associated with IGF-I levels. AIMS. To investigate whether IGF-I concentrations and the T1169A polymorphism of the GH1 gene are associated with cardiovascular risk factors and the intima media thickness (IMT) of the carotid artery. METHODS. Fasting plasma IGF-I concentrations (n=1008) were measured in a large population-based OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort. Genotype variants were determined by the restriction fragment length polymorphism method. RESULTS. Low IGF-I concentrations associated with several cardiovascular risk factors including age, adiposity, and high triglyceride, fasting insulin and C-reactive protein concentrations in the analysis of all subjects. In the multivariate models, however, IGF-I concentrations were positively associated with the mean IMT of women (β=0.127, P=0.009) whereas the association in men was weaker and negative (β=-0.088, P=0.034). The 1169A allele was associated with low low-density lipoprotein cholesterol in both sexes and with low systolic blood pressure levels in women. CONCLUSIONS. IGF-I concentrations were associated with several traditional cardiovascular risk factors. The observed gender difference in the association between IGF-I concentrations and carotid artery atherosclerosis warrants further study. The GH1 1169A allele may be associated with a favourable metabolic profile.

Affiliations:

Finlande

Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Association</term>
<term>Atherosclerosis</term>
<term>Atherosclerosis (blood)</term>
<term>Atherosclerosis (genetics)</term>
<term>Atherosclerosis (pathology)</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (genetics)</term>
<term>Cardiovascular Diseases (pathology)</term>
<term>Cardiovascular disease</term>
<term>Carotid</term>
<term>Carotid Arteries (pathology)</term>
<term>Carotid Artery Diseases (blood)</term>
<term>Carotid Artery Diseases (genetics)</term>
<term>Carotid Artery Diseases (pathology)</term>
<term>Concentration</term>
<term>Female</term>
<term>Growth Substances (genetics)</term>
<term>Humans</term>
<term>Insulin like growth factor 1</term>
<term>Insulin-Like Growth Factor I (analysis)</term>
<term>Insulin-Like Growth Factor I (metabolism)</term>
<term>Intima</term>
<term>Male</term>
<term>Medicine</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
<term>Thickness</term>
<term>Tunica Intima (pathology)</term>
<term>Tunica Media (pathology)</term>
<term>Vascular wall</term>
<term>Woman</term>
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<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Insulin-Like Growth Factor I</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Growth Substances</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
<term>Carotid Artery Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
<term>Carotid Artery Diseases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Insulin-Like Growth Factor I</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
<term>Carotid Arteries</term>
<term>Carotid Artery Diseases</term>
<term>Tunica Intima</term>
<term>Tunica Media</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Athérosclérose</term>
<term>Facteur croissance IGF1</term>
<term>Concentration</term>
<term>Association</term>
<term>Carotide</term>
<term>Femme</term>
<term>Femelle</term>
<term>Adulte</term>
<term>Appareil circulatoire pathologie</term>
<term>Paroi vasculaire</term>
<term>Intima</term>
<term>Epaisseur</term>
<term>Médecine</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Association</term>
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<term>Adulte</term>
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<front><div type="abstract" xml:lang="en">BACKGROUND. Alterations in the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis are associated with increased cardiovascular morbidity and mortality, but previous studies have yielded conflicting results. In addition, the T1169A polymorphism in the GH1 gene has been associated with IGF-I levels. AIMS. To investigate whether IGF-I concentrations and the T1169A polymorphism of the GH1 gene are associated with cardiovascular risk factors and the intima media thickness (IMT) of the carotid artery. METHODS. Fasting plasma IGF-I concentrations (n=1008) were measured in a large population-based OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort. Genotype variants were determined by the restriction fragment length polymorphism method. RESULTS. Low IGF-I concentrations associated with several cardiovascular risk factors including age, adiposity, and high triglyceride, fasting insulin and C-reactive protein concentrations in the analysis of all subjects. In the multivariate models, however, IGF-I concentrations were positively associated with the mean IMT of women (β=0.127, P=0.009) whereas the association in men was weaker and negative (β=-0.088, P=0.034). The 1169A allele was associated with low low-density lipoprotein cholesterol in both sexes and with low systolic blood pressure levels in women. CONCLUSIONS. IGF-I concentrations were associated with several traditional cardiovascular risk factors. The observed gender difference in the association between IGF-I concentrations and carotid artery atherosclerosis warrants further study. The GH1 1169A allele may be associated with a favourable metabolic profile.</div>
</front>
</TEI>
<affiliations><list><country><li>Finlande</li>
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<tree><country name="Finlande"><noRegion><name sortKey="Hietaniemi, Mirella" sort="Hietaniemi, Mirella" uniqKey="Hietaniemi M" first="Mirella" last="Hietaniemi">Mirella Hietaniemi</name>
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<name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y. Antero" last="Kes Niemi">Y. Antero Kes Niemi</name>
<name sortKey="P Iv Nsalo, Markku" sort="P Iv Nsalo, Markku" uniqKey="P Iv Nsalo M" first="Markku" last="P Iv Nsalo">Markku P Iv Nsalo</name>
<name sortKey="Poykko, Seppo M" sort="Poykko, Seppo M" uniqKey="Poykko S" first="Seppo M." last="Pöykkö">Seppo M. Pöykkö</name>
<name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name>
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IGF-I concentrations are positively associated with carotid artery atherosclerosis in women

IGF-I concentrations are positively associated with carotid artery atherosclerosis in women

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Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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