Serveur d'exploration sur l'opéra

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

IGF-I concentrations are positively associated with carotid artery atherosclerosis in women

Identifieur interne : 001B57 ( Main/Exploration ); précédent : 001B56; suivant : 001B58

IGF-I concentrations are positively associated with carotid artery atherosclerosis in women

Auteurs : Mirella Hietaniemi [Finlande] ; Seppo M. Pöykkö [Finlande] ; Olavi Ukkola [Finlande] ; Markku P Iv Nsalo [Finlande] ; Y. Antero Kes Niemi [Finlande]

Source :

RBID : Pascal:05-0414955

Descripteurs français

English descriptors

Abstract

BACKGROUND. Alterations in the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis are associated with increased cardiovascular morbidity and mortality, but previous studies have yielded conflicting results. In addition, the T1169A polymorphism in the GH1 gene has been associated with IGF-I levels. AIMS. To investigate whether IGF-I concentrations and the T1169A polymorphism of the GH1 gene are associated with cardiovascular risk factors and the intima media thickness (IMT) of the carotid artery. METHODS. Fasting plasma IGF-I concentrations (n=1008) were measured in a large population-based OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort. Genotype variants were determined by the restriction fragment length polymorphism method. RESULTS. Low IGF-I concentrations associated with several cardiovascular risk factors including age, adiposity, and high triglyceride, fasting insulin and C-reactive protein concentrations in the analysis of all subjects. In the multivariate models, however, IGF-I concentrations were positively associated with the mean IMT of women (β=0.127, P=0.009) whereas the association in men was weaker and negative (β=-0.088, P=0.034). The 1169A allele was associated with low low-density lipoprotein cholesterol in both sexes and with low systolic blood pressure levels in women. CONCLUSIONS. IGF-I concentrations were associated with several traditional cardiovascular risk factors. The observed gender difference in the association between IGF-I concentrations and carotid artery atherosclerosis warrants further study. The GH1 1169A allele may be associated with a favourable metabolic profile.


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en" level="a">IGF-I concentrations are positively associated with carotid artery atherosclerosis in women</title>
<author>
<name sortKey="Hietaniemi, Mirella" sort="Hietaniemi, Mirella" uniqKey="Hietaniemi M" first="Mirella" last="Hietaniemi">Mirella Hietaniemi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Poykko, Seppo M" sort="Poykko, Seppo M" uniqKey="Poykko S" first="Seppo M." last="Pöykkö">Seppo M. Pöykkö</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="P Iv Nsalo, Markku" sort="P Iv Nsalo, Markku" uniqKey="P Iv Nsalo M" first="Markku" last="P Iv Nsalo">Markku P Iv Nsalo</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Department of Diagnostic Radiology, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y. Antero" last="Kes Niemi">Y. Antero Kes Niemi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">INIST</idno>
<idno type="inist">05-0414955</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 05-0414955 INIST</idno>
<idno type="RBID">Pascal:05-0414955</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000394</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000209</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000343</idno>
<idno type="wicri:doubleKey">0785-3890:2005:Hietaniemi M:igf:i:concentrations</idno>
<idno type="wicri:Area/Main/Merge">001C04</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:16179273</idno>
<idno type="wicri:Area/PubMed/Corpus">000515</idno>
<idno type="wicri:Area/PubMed/Curation">000515</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000496</idno>
<idno type="wicri:Area/Ncbi/Merge">000356</idno>
<idno type="wicri:Area/Ncbi/Curation">000356</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000356</idno>
<idno type="wicri:doubleKey">0785-3890:2005:Hietaniemi M:igf:i:concentrations</idno>
<idno type="wicri:Area/Main/Merge">001A51</idno>
<idno type="wicri:Area/Main/Curation">001B57</idno>
<idno type="wicri:Area/Main/Exploration">001B57</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a">IGF-I concentrations are positively associated with carotid artery atherosclerosis in women</title>
<author>
<name sortKey="Hietaniemi, Mirella" sort="Hietaniemi, Mirella" uniqKey="Hietaniemi M" first="Mirella" last="Hietaniemi">Mirella Hietaniemi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Poykko, Seppo M" sort="Poykko, Seppo M" uniqKey="Poykko S" first="Seppo M." last="Pöykkö">Seppo M. Pöykkö</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="P Iv Nsalo, Markku" sort="P Iv Nsalo, Markku" uniqKey="P Iv Nsalo M" first="Markku" last="P Iv Nsalo">Markku P Iv Nsalo</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Department of Diagnostic Radiology, University of Oulu</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Oulu</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y. Antero" last="Kes Niemi">Y. Antero Kes Niemi</name>
<affiliation wicri:level="1">
<inist:fA14 i1="01">
<s1>Department of Internal Medicine and Biocenter</s1>
<s2>Oulu</s2>
<s3>FIN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>Finlande</country>
<wicri:noRegion>Department of Internal Medicine and Biocenter</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">Annals of medicine : (Helsinki)</title>
<title level="j" type="abbreviated">Ann. med. : (Hels.)</title>
<idno type="ISSN">0785-3890</idno>
<imprint>
<date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">Annals of medicine : (Helsinki)</title>
<title level="j" type="abbreviated">Ann. med. : (Hels.)</title>
<idno type="ISSN">0785-3890</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Adult</term>
<term>Association</term>
<term>Atherosclerosis</term>
<term>Atherosclerosis (blood)</term>
<term>Atherosclerosis (genetics)</term>
<term>Atherosclerosis (pathology)</term>
<term>Cardiovascular Diseases (blood)</term>
<term>Cardiovascular Diseases (genetics)</term>
<term>Cardiovascular Diseases (pathology)</term>
<term>Cardiovascular disease</term>
<term>Carotid</term>
<term>Carotid Arteries (pathology)</term>
<term>Carotid Artery Diseases (blood)</term>
<term>Carotid Artery Diseases (genetics)</term>
<term>Carotid Artery Diseases (pathology)</term>
<term>Concentration</term>
<term>Female</term>
<term>Growth Substances (genetics)</term>
<term>Humans</term>
<term>Insulin like growth factor 1</term>
<term>Insulin-Like Growth Factor I (analysis)</term>
<term>Insulin-Like Growth Factor I (metabolism)</term>
<term>Intima</term>
<term>Male</term>
<term>Medicine</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
<term>Thickness</term>
<term>Tunica Intima (pathology)</term>
<term>Tunica Media (pathology)</term>
<term>Vascular wall</term>
<term>Woman</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en">
<term>Insulin-Like Growth Factor I</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en">
<term>Growth Substances</term>
</keywords>
<keywords scheme="MESH" qualifier="blood" xml:lang="en">
<term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
<term>Carotid Artery Diseases</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en">
<term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
<term>Carotid Artery Diseases</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en">
<term>Insulin-Like Growth Factor I</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Atherosclerosis</term>
<term>Cardiovascular Diseases</term>
<term>Carotid Arteries</term>
<term>Carotid Artery Diseases</term>
<term>Tunica Intima</term>
<term>Tunica Media</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Polymorphism, Genetic</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Athérosclérose</term>
<term>Facteur croissance IGF1</term>
<term>Concentration</term>
<term>Association</term>
<term>Carotide</term>
<term>Femme</term>
<term>Femelle</term>
<term>Adulte</term>
<term>Appareil circulatoire pathologie</term>
<term>Paroi vasculaire</term>
<term>Intima</term>
<term>Epaisseur</term>
<term>Médecine</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Association</term>
<term>Femme</term>
<term>Adulte</term>
<term>Médecine</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">BACKGROUND. Alterations in the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis are associated with increased cardiovascular morbidity and mortality, but previous studies have yielded conflicting results. In addition, the T1169A polymorphism in the GH1 gene has been associated with IGF-I levels. AIMS. To investigate whether IGF-I concentrations and the T1169A polymorphism of the GH1 gene are associated with cardiovascular risk factors and the intima media thickness (IMT) of the carotid artery. METHODS. Fasting plasma IGF-I concentrations (n=1008) were measured in a large population-based OPERA (Oulu Project Elucidating Risk of Atherosclerosis) cohort. Genotype variants were determined by the restriction fragment length polymorphism method. RESULTS. Low IGF-I concentrations associated with several cardiovascular risk factors including age, adiposity, and high triglyceride, fasting insulin and C-reactive protein concentrations in the analysis of all subjects. In the multivariate models, however, IGF-I concentrations were positively associated with the mean IMT of women (β=0.127, P=0.009) whereas the association in men was weaker and negative (β=-0.088, P=0.034). The 1169A allele was associated with low low-density lipoprotein cholesterol in both sexes and with low systolic blood pressure levels in women. CONCLUSIONS. IGF-I concentrations were associated with several traditional cardiovascular risk factors. The observed gender difference in the association between IGF-I concentrations and carotid artery atherosclerosis warrants further study. The GH1 1169A allele may be associated with a favourable metabolic profile.</div>
</front>
</TEI>
<affiliations>
<list>
<country>
<li>Finlande</li>
</country>
</list>
<tree>
<country name="Finlande">
<noRegion>
<name sortKey="Hietaniemi, Mirella" sort="Hietaniemi, Mirella" uniqKey="Hietaniemi M" first="Mirella" last="Hietaniemi">Mirella Hietaniemi</name>
</noRegion>
<name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y. Antero" last="Kes Niemi">Y. Antero Kes Niemi</name>
<name sortKey="P Iv Nsalo, Markku" sort="P Iv Nsalo, Markku" uniqKey="P Iv Nsalo M" first="Markku" last="P Iv Nsalo">Markku P Iv Nsalo</name>
<name sortKey="Poykko, Seppo M" sort="Poykko, Seppo M" uniqKey="Poykko S" first="Seppo M." last="Pöykkö">Seppo M. Pöykkö</name>
<name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/explor/OperaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001B57 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001B57 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Musique
   |area=    OperaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:05-0414955
   |texte=   IGF-I concentrations are positively associated with carotid artery atherosclerosis in women
}}

Wicri

This area was generated with Dilib version V0.6.21.
Data generation: Thu Apr 14 14:59:05 2016. Site generation: Thu Oct 8 06:48:41 2020