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The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes

Identifieur interne : 001B48 ( Main/Exploration ); précédent : 001B47; suivant : 001B49

The negative association between plasma ghrelin and IGF-I is modified by obesity, insulin resistance and type 2 diabetes

Auteurs : S. M. Pöykkö [Finlande] ; O. Ukkola [Finlande] ; H. Kauma [Finlande] ; E. Kellokoski [Finlande] ; S. Hörkkö [Finlande] ; Y. A. Kes Niemi [Finlande]

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RBID : Pascal:05-0187795

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English descriptors

Abstract

Aims/hypothesis: Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association. Methods: We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI. Results: IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (β= -0.32, p<0.001) and after adjustments for BMI, insulin levels, sex and age (β=-0.40, p<0.001). The association was particularly strong in males and in the higher BMI tertiles. The degree of association varied in relation to the glycaemic status: no insulin resistance: r2=6.5% (p<0.001), insulin resistance without type 2 diabetes: r2=21.0% (p< 0.001), type 2 diabetes: r2=25.4 (p<0.001). IGF-I levels explained larger proportion (r2=9.8%) of the variation in ghrelin concentrations compared to fasting insulin concentration (r2=3.0%) and BMI (r2=1.5%). Conclusions/ interpretation: There is a negative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects. The interaction between IGF-I and ghrelin is modified by obesity, IR and type 2 diabetes. Further studies are warranted to elucidate the role of ghrelin in the development of these states.


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<term>Diabetes Mellitus, Type 2 (blood)</term>
<term>Female</term>
<term>Finland (epidemiology)</term>
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<term>Hormone</term>
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<keywords scheme="MESH" qualifier="blood" xml:lang="en">
<term>Diabetes Mellitus, Type 2</term>
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<term>Cohort Studies</term>
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<term>Humans</term>
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<term>Middle Aged</term>
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<term>Association</term>
<term>Ghréline</term>
<term>Facteur croissance IGF1</term>
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<term>Hormone</term>
<term>Protéine liaison IGFBP</term>
<term>Insulinoresistance</term>
<term>Etat nutritionnel</term>
<term>Diabète type 2</term>
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<div type="abstract" xml:lang="en">Aims/hypothesis: Ghrelin is a natural growth hormone-releasing peptide thought to be involved in the regulation of energy metabolism. The recent studies concerning the association between ghrelin and insulin-like growth factor-I (IGF-I) concentrations have shown either negative correlation or no correlation at all. The aims of this study were to clarify the association between ghrelin and IGF-I concentrations in a large cohort and to characterize whether obesity, insulin resistance and type 2 diabetes affect this association. Methods: We analysed fasting plasma ghrelin and IGF-I concentrations of 1,004 middle-aged subjects of the population-based OPERA study. Insulin resistance was estimated using QUICKI. Results: IGF-I concentrations were negatively associated with ghrelin concentrations in the analysis of all subjects before (β= -0.32, p<0.001) and after adjustments for BMI, insulin levels, sex and age (β=-0.40, p<0.001). The association was particularly strong in males and in the higher BMI tertiles. The degree of association varied in relation to the glycaemic status: no insulin resistance: r
<sup>2</sup>
=6.5% (p<0.001), insulin resistance without type 2 diabetes: r
<sup>2</sup>
=21.0% (p< 0.001), type 2 diabetes: r
<sup>2</sup>
=25.4 (p<0.001). IGF-I levels explained larger proportion (r
<sup>2</sup>
=9.8%) of the variation in ghrelin concentrations compared to fasting insulin concentration (r
<sup>2</sup>
=3.0%) and BMI (r
<sup>2</sup>
=1.5%). Conclusions/ interpretation: There is a negative and independent association between ghrelin and IGF-I concentrations in middle-aged subjects. The interaction between IGF-I and ghrelin is modified by obesity, IR and type 2 diabetes. Further studies are warranted to elucidate the role of ghrelin in the development of these states.</div>
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