Abnormal sensorimotor control, but intact force field adaptation, in multiple sclerosis subjects with no clinical disability.
Identifieur interne : 001381 ( Main/Exploration ); précédent : 001380; suivant : 001382Abnormal sensorimotor control, but intact force field adaptation, in multiple sclerosis subjects with no clinical disability.
Auteurs : Maura Casadio [Italie] ; Vittorio Sanguineti ; Pietro Morasso ; Claudio SolaroSource :
- Multiple sclerosis (Houndmills, Basingstoke, England) [ 1352-4585 ] ; 2008.
English descriptors
- KwdEn :
- Adaptation, Physiological (physiology), Adult, Disability Evaluation, Female, Hand (physiology), Humans, Male, Middle Aged, Models, Biological, Motor Neurons (physiology), Movement (physiology), Multiple Sclerosis, Relapsing-Remitting (physiopathology), Multiple Sclerosis, Relapsing-Remitting (rehabilitation), Neurons, Afferent (physiology), Physical Therapy Modalities (instrumentation), Predictive Value of Tests, Robotics.
- MESH :
- instrumentation : Physical Therapy Modalities.
- physiology : Adaptation, Physiological, Hand, Motor Neurons, Movement, Neurons, Afferent.
- physiopathology : Multiple Sclerosis, Relapsing-Remitting.
- rehabilitation : Multiple Sclerosis, Relapsing-Remitting.
- Adult, Disability Evaluation, Female, Humans, Male, Middle Aged, Models, Biological, Predictive Value of Tests, Robotics.
Abstract
In MS subjects with no clinical disability, we assessed sensorimotor organization and their ability to adapt to an unfamiliar dynamical environment. Eleven MS subjects performed reaching movements while a robot generated a speed-dependent force field. Control and adaptation performance were compared with that of an equal number of control subjects. During a familiarization phase, when the robot generated no forces, the movements of MS subjects were more curved, displayed greater and more variable directional errors and a longer deceleration phase. During the force field phase, both MS and control subjects gradually learned to predict the robot-generated forces. The rates of adaptation were similar, but MS subjects showed a greater variability in responding to the force field. These results suggest that MS subjects have a preserved capability of learning to predict the effects of the forces, but make greater errors when actually using such predictions to generate movements. Inaccurate motor commands are then compensated later in the movement through an extra amount of sensory-based corrections. This indicates that early in the disease MS subjects have intact adaptive capabilities, but impaired movement execution.
DOI: 10.1177/1352458507085068
PubMed: 18208874
Affiliations:
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Le document en format XML
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last="Sanguineti">Vittorio Sanguineti</name></author><author><name sortKey="Morasso, Pietro" sort="Morasso, Pietro" uniqKey="Morasso P" first="Pietro" last="Morasso">Pietro Morasso</name></author><author><name sortKey="Solaro, Claudio" sort="Solaro, Claudio" uniqKey="Solaro C" first="Claudio" last="Solaro">Claudio Solaro</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1177/1352458507085068</idno><idno type="RBID">pubmed:18208874</idno><idno type="pmid">18208874</idno><idno type="wicri:Area/PubMed/Corpus">000440</idno><idno type="wicri:Area/PubMed/Curation">000440</idno><idno type="wicri:Area/PubMed/Checkpoint">000426</idno><idno type="wicri:Area/Ncbi/Merge">000477</idno><idno type="wicri:Area/Ncbi/Curation">000477</idno><idno type="wicri:Area/Ncbi/Checkpoint">000477</idno><idno type="wicri:doubleKey">1352-4585:2008:Casadio M:abnormal:sensorimotor:control</idno><idno 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16145</wicri:noRegion></affiliation></author><author><name sortKey="Sanguineti, Vittorio" sort="Sanguineti, Vittorio" uniqKey="Sanguineti V" first="Vittorio" last="Sanguineti">Vittorio Sanguineti</name></author><author><name sortKey="Morasso, Pietro" sort="Morasso, Pietro" uniqKey="Morasso P" first="Pietro" last="Morasso">Pietro Morasso</name></author><author><name sortKey="Solaro, Claudio" sort="Solaro, Claudio" uniqKey="Solaro C" first="Claudio" last="Solaro">Claudio Solaro</name></author></analytic><series><title level="j">Multiple sclerosis (Houndmills, Basingstoke, England)</title><idno type="ISSN">1352-4585</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (physiology)</term><term>Adult</term><term>Disability Evaluation</term><term>Female</term><term>Hand (physiology)</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Motor Neurons (physiology)</term><term>Movement (physiology)</term><term>Multiple Sclerosis, Relapsing-Remitting (physiopathology)</term><term>Multiple Sclerosis, Relapsing-Remitting (rehabilitation)</term><term>Neurons, Afferent (physiology)</term><term>Physical Therapy Modalities (instrumentation)</term><term>Predictive Value of Tests</term><term>Robotics</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Physical Therapy Modalities</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Physiological</term><term>Hand</term><term>Motor Neurons</term><term>Movement</term><term>Neurons, Afferent</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Multiple Sclerosis, Relapsing-Remitting</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Multiple Sclerosis, Relapsing-Remitting</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Disability Evaluation</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Models, Biological</term><term>Predictive Value of Tests</term><term>Robotics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In MS subjects with no clinical disability, we assessed sensorimotor organization and their ability to adapt to an unfamiliar dynamical environment. Eleven MS subjects performed reaching movements while a robot generated a speed-dependent force field. Control and adaptation performance were compared with that of an equal number of control subjects. During a familiarization phase, when the robot generated no forces, the movements of MS subjects were more curved, displayed greater and more variable directional errors and a longer deceleration phase. During the force field phase, both MS and control subjects gradually learned to predict the robot-generated forces. The rates of adaptation were similar, but MS subjects showed a greater variability in responding to the force field. These results suggest that MS subjects have a preserved capability of learning to predict the effects of the forces, but make greater errors when actually using such predictions to generate movements. Inaccurate motor commands are then compensated later in the movement through an extra amount of sensory-based corrections. This indicates that early in the disease MS subjects have intact adaptive capabilities, but impaired movement execution.</div></front></TEI><affiliations><list><country><li>Italie</li></country></list><tree><noCountry><name sortKey="Morasso, Pietro" sort="Morasso, Pietro" uniqKey="Morasso P" first="Pietro" last="Morasso">Pietro Morasso</name><name sortKey="Sanguineti, Vittorio" sort="Sanguineti, Vittorio" uniqKey="Sanguineti V" first="Vittorio" last="Sanguineti">Vittorio Sanguineti</name><name sortKey="Solaro, Claudio" sort="Solaro, Claudio" uniqKey="Solaro C" first="Claudio" last="Solaro">Claudio Solaro</name></noCountry><country name="Italie"><noRegion><name sortKey="Casadio, Maura" sort="Casadio, Maura" uniqKey="Casadio M" first="Maura" last="Casadio">Maura Casadio</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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