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Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.

Identifieur interne : 000D58 ( Main/Exploration ); précédent : 000D57; suivant : 000D59

Leptin receptor Lys109Arg and Gln223Arg polymorphisms are associated with early atherosclerosis.

Auteurs : Meiju Saukko [Finlande] ; Y Antero Kes Niemi ; Olavi Ukkola

Source :

RBID : pubmed:20874424

English descriptors

Abstract

Leptin is a hormone expressed by the leptin gene, primarily in adipocytes, controlling food intake and energy expenditure. The effects of leptin are mediated by its receptor (LEPR) located in the central nervous system and other tissues, including adipocytes and endothelial cells. The aim of this study was to characterize two polymorphisms of LEPR, Lys109Arg (rs1137100) and Gln223Arg (rs1137101), as risk factors for early atherosclerosis. This connection has not been studied before.

DOI: 10.1089/met.2010.0004
PubMed: 20874424


Affiliations:


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Le document en format XML

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<name sortKey="Saukko, Meiju" sort="Saukko, Meiju" uniqKey="Saukko M" first="Meiju" last="Saukko">Meiju Saukko</name>
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<nlm:affiliation>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland.</nlm:affiliation>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>Institute of Clinical Medicine, Department of Internal Medicine and Biocenter Oulu, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu</wicri:regionArea>
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<name sortKey="Kes Niemi, Y Antero" sort="Kes Niemi, Y Antero" uniqKey="Kes Niemi Y" first="Y Antero" last="Kes Niemi">Y Antero Kes Niemi</name>
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<name sortKey="Ukkola, Olavi" sort="Ukkola, Olavi" uniqKey="Ukkola O" first="Olavi" last="Ukkola">Olavi Ukkola</name>
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<title level="j">Metabolic syndrome and related disorders</title>
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<term>Adipocytes (cytology)</term>
<term>Arginine (chemistry)</term>
<term>Atherosclerosis (blood)</term>
<term>Atherosclerosis (genetics)</term>
<term>Blood Pressure</term>
<term>Body Mass Index</term>
<term>Endothelial Cells (cytology)</term>
<term>Female</term>
<term>Glutamine (chemistry)</term>
<term>Humans</term>
<term>Leptin (blood)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Models, Genetic</term>
<term>Polymorphism, Genetic</term>
<term>Random Allocation</term>
<term>Receptors, Leptin (chemistry)</term>
<term>Risk Factors</term>
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<term>Leptin</term>
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<term>Arginine</term>
<term>Glutamine</term>
<term>Receptors, Leptin</term>
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<term>Atherosclerosis</term>
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<term>Body Mass Index</term>
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<term>Humans</term>
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