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Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial.

Identifieur interne : 000554 ( Main/Exploration ); précédent : 000553; suivant : 000555

Plasma phospholipid omega-3 fatty acids and incidence of postoperative atrial fibrillation in the OPERA trial.

Auteurs : Jason H Y. Wu [États-Unis] ; Roberto Marchioli ; Maria G. Silletta ; Alejandro Macchia ; Xiaoling Song ; David S. Siscovick ; William S. Harris ; Serge Masson ; Roberto Latini ; Christine Albert ; Nancy J. Brown ; Mauro Lamarra ; Roberto R. Favaloro ; Dariush Mozaffarian

Source :

RBID : pubmed:24145742

English descriptors

Abstract

Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA) demonstrated antiarrhythmic potential in experimental studies. In a large multinational randomized trial (OPERA), perioperative fish oil supplementation did not reduce the risk of postoperative atrial fibrillation (PoAF) in cardiac surgery patients. However, whether presupplementation habitual plasma phospholipid n-3 PUFA, or achieved or change in n-3 PUFA level postsupplementation are associated with lower risk of PoAF is unknown.

DOI: 10.1161/JAHA.113.000397
PubMed: 24145742


Affiliations:


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Le document en format XML

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<nlm:affiliation>Department of Epidemiology, Harvard School of Public Health, Boston, MA.</nlm:affiliation>
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<term>Cardiac Surgical Procedures</term>
<term>Dietary Supplements</term>
<term>Docosahexaenoic Acids (blood)</term>
<term>Eicosapentaenoic Acid (blood)</term>
<term>Fatty Acids, Unsaturated (blood)</term>
<term>Female</term>
<term>Fish Oils (administration & dosage)</term>
<term>Humans</term>
<term>Incidence</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Postoperative Complications (blood)</term>
<term>Postoperative Complications (epidemiology)</term>
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<term>Fish Oils</term>
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<term>Docosahexaenoic Acids</term>
<term>Eicosapentaenoic Acid</term>
<term>Fatty Acids, Unsaturated</term>
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<div type="abstract" xml:lang="en">Long-chain polyunsaturated omega-3 fatty acids (n-3 PUFA) demonstrated antiarrhythmic potential in experimental studies. In a large multinational randomized trial (OPERA), perioperative fish oil supplementation did not reduce the risk of postoperative atrial fibrillation (PoAF) in cardiac surgery patients. However, whether presupplementation habitual plasma phospholipid n-3 PUFA, or achieved or change in n-3 PUFA level postsupplementation are associated with lower risk of PoAF is unknown.</div>
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