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Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.

Identifieur interne : 000434 ( Main/Exploration ); précédent : 000433; suivant : 000435

Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.

Auteurs : Kim H Rslev-Petersen [Danemark] ; Merete Lund Hetland ; Peter Junker ; Jan P Denphant ; Torkell Ellingsen ; Palle Ahlquist ; Hanne Lindegaard ; Asta Linauskas ; Annette Schlemmer ; Mette Yde Dam ; Ib Hansen ; Hans Christian Horn ; Christian Gytz Ammitzb Ll ; Anette J Rgensen ; Sophine B. Krintel ; Johnny Raun ; Julia S. Johansen ; Mikkel Stergaard ; Kristian Stengaard-Pedersen

Source :

RBID : pubmed:23434570

Mots-clés :

Abstract

An investigator-initiated, double-blinded, placebo-controlled, treat-to-target protocol (Clinical Trials:NCT00660647) studied whether adalimumab added to methotrexate and intra-articular triamcinolone as first-line treatment in early rheumatoid arthritis (ERA) increased the frequency of low disease activity (DAS28CRP<3.2) at 12 months.


DOI: 10.1136/annrheumdis-2012-202735


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<title xml:lang="en">Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.</title>
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<nlm:affiliation>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, , Gråsten, Denmark; South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, , Odense, Denmark.</nlm:affiliation>
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<name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
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<title xml:lang="en">Adalimumab added to a treat-to-target strategy with methotrexate and intra-articular triamcinolone in early rheumatoid arthritis increased remission rates, function and quality of life. The OPERA Study: an investigator-initiated, randomised, double-blind, parallel-group, placebo-controlled trial.</title>
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<nlm:affiliation>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, , Gråsten, Denmark; South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, , Odense, Denmark.</nlm:affiliation>
<country xml:lang="fr">Danemark</country>
<wicri:regionArea>Department of Rheumatology, King Christian 10th Hospital for Rheumatic Diseases, , Gråsten, Denmark; South Jutland Hospital, Institute of Regional Health Services Research, University of Southern Denmark, , Odense</wicri:regionArea>
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<name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
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<name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name>
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<name sortKey="Dam, Mette Yde" sort="Dam, Mette Yde" uniqKey="Dam M" first="Mette Yde" last="Dam">Mette Yde Dam</name>
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<name sortKey="Horn, Hans Christian" sort="Horn, Hans Christian" uniqKey="Horn H" first="Hans Christian" last="Horn">Hans Christian Horn</name>
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<name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name>
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<name sortKey="Raun, Johnny" sort="Raun, Johnny" uniqKey="Raun J" first="Johnny" last="Raun">Johnny Raun</name>
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<name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name>
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<name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
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<title level="j">Annals of the rheumatic diseases</title>
<idno type="e-ISSN">1468-2060</idno>
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<term>Adalimumab</term>
<term>Adult</term>
<term>Aged</term>
<term>Antibodies, Monoclonal, Humanized (administration & dosage)</term>
<term>Antibodies, Monoclonal, Humanized (adverse effects)</term>
<term>Antibodies, Monoclonal, Humanized (therapeutic use)</term>
<term>Antirheumatic Agents (administration & dosage)</term>
<term>Antirheumatic Agents (adverse effects)</term>
<term>Antirheumatic Agents (therapeutic use)</term>
<term>Arthritis, Rheumatoid (drug therapy)</term>
<term>Arthritis, Rheumatoid (physiopathology)</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
<term>Drug Therapy, Combination</term>
<term>Female</term>
<term>Humans</term>
<term>Injections, Intra-Articular</term>
<term>Male</term>
<term>Methotrexate (administration & dosage)</term>
<term>Methotrexate (adverse effects)</term>
<term>Methotrexate (therapeutic use)</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Remission Induction</term>
<term>Severity of Illness Index</term>
<term>Treatment Outcome</term>
<term>Triamcinolone (administration & dosage)</term>
<term>Triamcinolone (adverse effects)</term>
<term>Triamcinolone (therapeutic use)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en">
<term>Antibodies, Monoclonal, Humanized</term>
<term>Antirheumatic Agents</term>
<term>Methotrexate</term>
<term>Triamcinolone</term>
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<keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en">
<term>Antibodies, Monoclonal, Humanized</term>
<term>Antirheumatic Agents</term>
<term>Methotrexate</term>
<term>Triamcinolone</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en">
<term>Antibodies, Monoclonal, Humanized</term>
<term>Antirheumatic Agents</term>
<term>Methotrexate</term>
<term>Triamcinolone</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en">
<term>Adalimumab</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en">
<term>Arthritis, Rheumatoid</term>
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<term>Arthritis, Rheumatoid</term>
</keywords>
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<term>Aged</term>
<term>Double-Blind Method</term>
<term>Drug Administration Schedule</term>
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<term>Female</term>
<term>Humans</term>
<term>Injections, Intra-Articular</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Quality of Life</term>
<term>Remission Induction</term>
<term>Severity of Illness Index</term>
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<front>
<div type="abstract" xml:lang="en">An investigator-initiated, double-blinded, placebo-controlled, treat-to-target protocol (Clinical Trials:NCT00660647) studied whether adalimumab added to methotrexate and intra-articular triamcinolone as first-line treatment in early rheumatoid arthritis (ERA) increased the frequency of low disease activity (DAS28CRP<3.2) at 12 months.</div>
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<li>Danemark</li>
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<name sortKey=" Stergaard, Mikkel" sort=" Stergaard, Mikkel" uniqKey=" Stergaard M" first="Mikkel" last=" Stergaard">Mikkel Stergaard</name>
<name sortKey="Ahlquist, Palle" sort="Ahlquist, Palle" uniqKey="Ahlquist P" first="Palle" last="Ahlquist">Palle Ahlquist</name>
<name sortKey="Ammitzb Ll, Christian Gytz" sort="Ammitzb Ll, Christian Gytz" uniqKey="Ammitzb Ll C" first="Christian Gytz" last="Ammitzb Ll">Christian Gytz Ammitzb Ll</name>
<name sortKey="Dam, Mette Yde" sort="Dam, Mette Yde" uniqKey="Dam M" first="Mette Yde" last="Dam">Mette Yde Dam</name>
<name sortKey="Ellingsen, Torkell" sort="Ellingsen, Torkell" uniqKey="Ellingsen T" first="Torkell" last="Ellingsen">Torkell Ellingsen</name>
<name sortKey="Hansen, Ib" sort="Hansen, Ib" uniqKey="Hansen I" first="Ib" last="Hansen">Ib Hansen</name>
<name sortKey="Hetland, Merete Lund" sort="Hetland, Merete Lund" uniqKey="Hetland M" first="Merete Lund" last="Hetland">Merete Lund Hetland</name>
<name sortKey="Horn, Hans Christian" sort="Horn, Hans Christian" uniqKey="Horn H" first="Hans Christian" last="Horn">Hans Christian Horn</name>
<name sortKey="J Rgensen, Anette" sort="J Rgensen, Anette" uniqKey="J Rgensen A" first="Anette" last="J Rgensen">Anette J Rgensen</name>
<name sortKey="Johansen, Julia S" sort="Johansen, Julia S" uniqKey="Johansen J" first="Julia S" last="Johansen">Julia S. Johansen</name>
<name sortKey="Junker, Peter" sort="Junker, Peter" uniqKey="Junker P" first="Peter" last="Junker">Peter Junker</name>
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<name sortKey="Lindegaard, Hanne" sort="Lindegaard, Hanne" uniqKey="Lindegaard H" first="Hanne" last="Lindegaard">Hanne Lindegaard</name>
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<name sortKey="Schlemmer, Annette" sort="Schlemmer, Annette" uniqKey="Schlemmer A" first="Annette" last="Schlemmer">Annette Schlemmer</name>
<name sortKey="Stengaard Pedersen, Kristian" sort="Stengaard Pedersen, Kristian" uniqKey="Stengaard Pedersen K" first="Kristian" last="Stengaard-Pedersen">Kristian Stengaard-Pedersen</name>
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<noRegion>
<name sortKey="H Rslev Petersen, Kim" sort="H Rslev Petersen, Kim" uniqKey="H Rslev Petersen K" first="Kim" last="H Rslev-Petersen">Kim H Rslev-Petersen</name>
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