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Combination of Paeoniae Radix and Cnidii Rhizoma Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice

Identifieur interne : 000414 ( Main/Exploration ); précédent : 000413; suivant : 000415

Combination of Paeoniae Radix and Cnidii Rhizoma Prolonged Survival of Fully Mismatched Cardiac Allografts and Generated Regulatory Cells in Mice

Auteurs : Xiangyuan Jin [Japon, République populaire de Chine] ; Lei Yu [Japon, République populaire de Chine] ; Masateru Uchiyama [Japon] ; Enzhi Yin [Japon, République populaire de Chine] ; Tadanori Harada [Japon] ; Ken Otsuka [Japon] ; Shigefumi Matsuyama [Japon] ; Tomohiro Imazuru [Japon] ; Tomoki Shimokawa [Japon] ; Masanori Niimi [Japon]

Source :

RBID : PMC:3977559

Abstract

In previous studies, we have demonstrated that Tokishakuyakusan (TJ-23) can prolong the survival of allogeneic cardiac grafts and induce regulatory T cells. In this study we investigated the effects of Paeoniae radix and Cnidii rhizoma, two components of TJ-23, on alloimmune responses in a murine cardiac transplantation model and whether the two agents have synergistic effect. CBA mice underwent transplantation of a C57BL/6 heart and received oral administration of 2 g/kg/day of Paeoniae radix, Cnidii rhizoma, or the mixture of two agents from the day of transplantation until 7 days afterward. Naïve CBA mice rejected C57BL/6 cardiac graft acutely (median survival time (MST): 7 days). Paeoniae radix and Cnidii rhizoma prolonged C57BL/6 allograft survival (MSTs: 13.5 and 15.5 days, resp.). However, the mixture of two agents prolonged C57BL/6 allograft survival indefinitely (MST > 100 days). Secondary CBA recipients given whole splenocytes from primary combination-treated CBA recipients with B6 cardiac allografts 30 days after grafting had prolonged survival of B6 hearts (MST: 33 days). Flow cytometry studies showed that the CD4+CD25+Foxp3+ regulatory cell population was increased in combination-treated recipients. Combination of Paeoniae radix and Cnidii rhizoma induced hyporesponsiveness to fully allogeneic cardiac allografts and may generate CD4+CD25+Foxp3+ regulatory cells in our model.


Url:
DOI: 10.1155/2014/841408
PubMed: 24772184
PubMed Central: 3977559


Affiliations:


Links toward previous steps (curation, corpus...)


Le document en format XML

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<name sortKey="Yin, Enzhi" sort="Yin, Enzhi" uniqKey="Yin E" first="Enzhi" last="Yin">Enzhi Yin</name>
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<name sortKey="Harada, Tadanori" sort="Harada, Tadanori" uniqKey="Harada T" first="Tadanori" last="Harada">Tadanori Harada</name>
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<name sortKey="Otsuka, Ken" sort="Otsuka, Ken" uniqKey="Otsuka K" first="Ken" last="Otsuka">Ken Otsuka</name>
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<name sortKey="Matsuyama, Shigefumi" sort="Matsuyama, Shigefumi" uniqKey="Matsuyama S" first="Shigefumi" last="Matsuyama">Shigefumi Matsuyama</name>
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<p>In previous studies, we have demonstrated that Tokishakuyakusan (TJ-23) can prolong the survival of allogeneic cardiac grafts and induce regulatory T cells. In this study we investigated the effects of Paeoniae radix and Cnidii rhizoma, two components of TJ-23, on alloimmune responses in a murine cardiac transplantation model and whether the two agents have synergistic effect. CBA mice underwent transplantation of a C57BL/6 heart and received oral administration of 2 g/kg/day of Paeoniae radix, Cnidii rhizoma, or the mixture of two agents from the day of transplantation until 7 days afterward. Naïve CBA mice rejected C57BL/6 cardiac graft acutely (median survival time (MST): 7 days). Paeoniae radix and Cnidii rhizoma prolonged C57BL/6 allograft survival (MSTs: 13.5 and 15.5 days, resp.). However, the mixture of two agents prolonged C57BL/6 allograft survival indefinitely (MST > 100 days). Secondary CBA recipients given whole splenocytes from primary combination-treated CBA recipients with B6 cardiac allografts 30 days after grafting had prolonged survival of B6 hearts (MST: 33 days). Flow cytometry studies showed that the CD4
<sup>+</sup>
CD25
<sup>+</sup>
Foxp3
<sup>+</sup>
regulatory cell population was increased in combination-treated recipients. Combination of Paeoniae radix and Cnidii rhizoma induced hyporesponsiveness to fully allogeneic cardiac allografts and may generate CD4
<sup>+</sup>
CD25
<sup>+</sup>
Foxp3
<sup>+</sup>
regulatory cells in our model.</p>
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<name sortKey="Lee, Kk" uniqKey="Lee K">KK Lee</name>
</author>
<author>
<name sortKey="Omiya, Y" uniqKey="Omiya Y">Y Omiya</name>
</author>
<author>
<name sortKey="Yuzurihara, M" uniqKey="Yuzurihara M">M Yuzurihara</name>
</author>
<author>
<name sortKey="Kase, Y" uniqKey="Kase Y">Y Kase</name>
</author>
<author>
<name sortKey="Kobayashi, H" uniqKey="Kobayashi H">H Kobayashi</name>
</author>
</analytic>
</biblStruct>
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<analytic>
<author>
<name sortKey="Uchiyama, M" uniqKey="Uchiyama M">M Uchiyama</name>
</author>
<author>
<name sortKey="Jin, X" uniqKey="Jin X">X Jin</name>
</author>
<author>
<name sortKey="Zhang, Q" uniqKey="Zhang Q">Q Zhang</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Stewart, S" uniqKey="Stewart S">S Stewart</name>
</author>
<author>
<name sortKey="Winters, Gl" uniqKey="Winters G">GL Winters</name>
</author>
<author>
<name sortKey="Fishbein, Mc" uniqKey="Fishbein M">MC Fishbein</name>
</author>
</analytic>
</biblStruct>
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<analytic>
<author>
<name sortKey="Billingham, Me" uniqKey="Billingham M">ME Billingham</name>
</author>
<author>
<name sortKey="Cary, Nrb" uniqKey="Cary N">NRB Cary</name>
</author>
<author>
<name sortKey="Hammond, Me" uniqKey="Hammond M">ME Hammond</name>
</author>
</analytic>
</biblStruct>
<biblStruct>
<analytic>
<author>
<name sortKey="Akiyama, Y" uniqKey="Akiyama Y">Y Akiyama</name>
</author>
<author>
<name sortKey="Shirasugi, N" uniqKey="Shirasugi N">N Shirasugi</name>
</author>
<author>
<name sortKey="Uchida, N" uniqKey="Uchida N">N Uchida</name>
</author>
</analytic>
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<analytic>
<author>
<name sortKey="Itoh, M" uniqKey="Itoh M">M Itoh</name>
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<author>
<name sortKey="Takahashi, T" uniqKey="Takahashi T">T Takahashi</name>
</author>
<author>
<name sortKey="Sakaguchi, N" uniqKey="Sakaguchi N">N Sakaguchi</name>
</author>
</analytic>
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<name sortKey="Wood, Kj" uniqKey="Wood K">KJ Wood</name>
</author>
<author>
<name sortKey="Sakaguchi, S" uniqKey="Sakaguchi S">S Sakaguchi</name>
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</analytic>
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<analytic>
<author>
<name sortKey="Madsen, Jc" uniqKey="Madsen J">JC Madsen</name>
</author>
<author>
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<name sortKey="Fallon, Jt" uniqKey="Fallon J">JT Fallon</name>
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<name sortKey="Weissman, Nj" uniqKey="Weissman N">NJ Weissman</name>
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</analytic>
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<author>
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<author>
<name sortKey="Yamada, K" uniqKey="Yamada K">K Yamada</name>
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<author>
<name sortKey="Madsen, Jc" uniqKey="Madsen J">JC Madsen</name>
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</analytic>
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<author>
<name sortKey="King, Cl" uniqKey="King C">CL King</name>
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<author>
<name sortKey="Devitt, Jj" uniqKey="Devitt J">JJ Devitt</name>
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<name sortKey="Hancock Friesen, Cl" uniqKey="Hancock Friesen C">CL Hancock Friesen</name>
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<author>
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<author>
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<name sortKey="Gorman, Rc" uniqKey="Gorman R">RC Gorman</name>
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<biblStruct>
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<author>
<name sortKey="Devitt, Jj" uniqKey="Devitt J">JJ Devitt</name>
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<author>
<name sortKey="King, Cl" uniqKey="King C">CL King</name>
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<name sortKey="Hancock Friesen, Cl" uniqKey="Hancock Friesen C">CL Hancock Friesen</name>
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</analytic>
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<analytic>
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<author>
<name sortKey="Chen, Y" uniqKey="Chen Y">Y Chen</name>
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<biblStruct>
<analytic>
<author>
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</analytic>
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<biblStruct>
<analytic>
<author>
<name sortKey="Sun, Y" uniqKey="Sun Y">Y Sun</name>
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<biblStruct>
<analytic>
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<biblStruct>
<analytic>
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<biblStruct>
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</author>
</analytic>
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</listBibl>
</div1>
</back>
</TEI>
<affiliations>
<list>
<country>
<li>Japon</li>
<li>République populaire de Chine</li>
</country>
<settlement>
<li>Tokyo</li>
</settlement>
</list>
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<country name="Japon">
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<name sortKey="Jin, Xiangyuan" sort="Jin, Xiangyuan" uniqKey="Jin X" first="Xiangyuan" last="Jin">Xiangyuan Jin</name>
</noRegion>
<name sortKey="Harada, Tadanori" sort="Harada, Tadanori" uniqKey="Harada T" first="Tadanori" last="Harada">Tadanori Harada</name>
<name sortKey="Imazuru, Tomohiro" sort="Imazuru, Tomohiro" uniqKey="Imazuru T" first="Tomohiro" last="Imazuru">Tomohiro Imazuru</name>
<name sortKey="Matsuyama, Shigefumi" sort="Matsuyama, Shigefumi" uniqKey="Matsuyama S" first="Shigefumi" last="Matsuyama">Shigefumi Matsuyama</name>
<name sortKey="Niimi, Masanori" sort="Niimi, Masanori" uniqKey="Niimi M" first="Masanori" last="Niimi">Masanori Niimi</name>
<name sortKey="Otsuka, Ken" sort="Otsuka, Ken" uniqKey="Otsuka K" first="Ken" last="Otsuka">Ken Otsuka</name>
<name sortKey="Shimokawa, Tomoki" sort="Shimokawa, Tomoki" uniqKey="Shimokawa T" first="Tomoki" last="Shimokawa">Tomoki Shimokawa</name>
<name sortKey="Uchiyama, Masateru" sort="Uchiyama, Masateru" uniqKey="Uchiyama M" first="Masateru" last="Uchiyama">Masateru Uchiyama</name>
<name sortKey="Uchiyama, Masateru" sort="Uchiyama, Masateru" uniqKey="Uchiyama M" first="Masateru" last="Uchiyama">Masateru Uchiyama</name>
<name sortKey="Yin, Enzhi" sort="Yin, Enzhi" uniqKey="Yin E" first="Enzhi" last="Yin">Enzhi Yin</name>
<name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
</country>
<country name="République populaire de Chine">
<noRegion>
<name sortKey="Jin, Xiangyuan" sort="Jin, Xiangyuan" uniqKey="Jin X" first="Xiangyuan" last="Jin">Xiangyuan Jin</name>
</noRegion>
<name sortKey="Yin, Enzhi" sort="Yin, Enzhi" uniqKey="Yin E" first="Enzhi" last="Yin">Enzhi Yin</name>
<name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
</country>
</tree>
</affiliations>
</record>

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