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Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.

Identifieur interne : 000017 ( Main/Exploration ); précédent : 000016; suivant : 000018

Serum levels of C-terminal agrin fragment (CAF) are associated with sarcopenia in older multimorbid community-dwellers: Results from the ilSIRENTE study.

Auteurs : Francesco Landi [Italie] ; Riccardo Calvani [Italie] ; Maria Lorenzi [Italie] ; Anna Maria Martone [Italie] ; Matteo Tosato [Italie] ; Michael Drey [Allemagne] ; Emanuela D'Angelo [Italie] ; Ettore Capoluongo [Italie] ; Andrea Russo [Italie] ; Roberto Bernabei [Italie] ; Graziano Onder [Italie] ; Emanuele Marzetti [Italie]

Source :

RBID : pubmed:27015736

Abstract

The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community.


DOI: 10.1016/j.exger.2016.03.012


Affiliations:


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<div type="abstract" xml:lang="en">The C-terminal agrin fragment (CAF), a circulating byproduct of neuromuscular junction disassembly, has been proposed as a possible biomarker for sarcopenia. However, its validity in "real-world", multimorbid older persons is currently unknown. The present study was undertaken to verify if serum CAF levels were associated with sarcopenia in a population of old and very old persons living in the community.</div>
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