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Functional connectivity and dynamics of corticalthalamic networks co-cultured in a dual compartment device

Identifieur interne : 000861 ( Main/Curation ); précédent : 000860; suivant : 000862

Functional connectivity and dynamics of corticalthalamic networks co-cultured in a dual compartment device

Auteurs : Thirukumaran T. Kanagasabapathi ; Paolo Massobrio ; Rocco Andrea Barone ; Mariateresa Tedesco ; Sergio Martinoia ; Wytse J. Wadman [Pays-Bas] ; Michel M J. Decr

Source :

RBID : ISTEX:58C0FC4E994EFA7F39AEB50D4EA21612501BC4C7

Abstract

Co-cultures containing dissociated cortical and thalamic cells may provide a unique model for understanding the pathophysiology in the respective neuronal sub-circuitry. In addition, developing an in vitro dissociated co-culture model offers the possibility of studying the system without influence from other neuronal sub-populations. Here we demonstrate a dual compartment system coupled to microelectrode arrays (MEAs) for co-culturing and recording spontaneous activities from neuronal sub-populations. Propagation of electrical activities between cortical and thalamic regions and their interdependence in connectivity is verified by means of a cross-correlation algorithm. We found that burst events originate in the cortical region and drive the entire corticalthalamic network bursting behavior while mutually weak thalamic connections play a relevant role in sustaining longer burst events in cortical cells. To support these experimental findings, a neuronal network model was developed and used to investigate the interplay between network dynamics and connectivity in the corticalthalamic system.

Url:
DOI: 10.1088/1741-2560/9/3/036010

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ISTEX:58C0FC4E994EFA7F39AEB50D4EA21612501BC4C7

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Thirukumaran T. Kanagasabapathi
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Paolo Massobrio
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Rocco Andrea Barone
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Mariateresa Tedesco
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Sergio Martinoia
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Michel M J. Decr
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