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In vitro influence of benfluorex and its main metabolites on rat liver microsomal membrane properties

Identifieur interne : 000144 ( France/Analysis ); précédent : 000143; suivant : 000145

In vitro influence of benfluorex and its main metabolites on rat liver microsomal membrane properties

Auteurs : Thierry Orsière [France] ; Michèle Chauvet [France] ; Monique Dell'Amico [France] ; Huguette Lafont [France] ; Madeleine Bourdeaux [France]

Source :

RBID : ISTEX:900E8450B99DEBF065F1AE2E0E01ECF2E5923394

Mots-clés :

Abstract

Benfluorex and its three main metabolites at 30 μM have been shown to inhibit Acyl CoA cholesterol acyl transferase activity in rat liver microsome preparations and to fluidize these membranes, as reflected by a decrease in the lipid order parameter. When drug concentrations were higher (60–200 μM), the compounds differed in their enzymatic inhibition properties but retained the same fluidizing effects. Only the parent compound had a dose-dependent inhibiting effect. These results are discussed with regard to the chemical properties of compounds, in particular their electric charges and their lipophilic characters.


Url:
DOI: 10.1016/0009-2797(95)03624-U


Affiliations:


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ISTEX:900E8450B99DEBF065F1AE2E0E01ECF2E5923394

Le document en format XML

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<div type="abstract" xml:lang="en">Benfluorex and its three main metabolites at 30 μM have been shown to inhibit Acyl CoA cholesterol acyl transferase activity in rat liver microsome preparations and to fluidize these membranes, as reflected by a decrease in the lipid order parameter. When drug concentrations were higher (60–200 μM), the compounds differed in their enzymatic inhibition properties but retained the same fluidizing effects. Only the parent compound had a dose-dependent inhibiting effect. These results are discussed with regard to the chemical properties of compounds, in particular their electric charges and their lipophilic characters.</div>
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EXPLOR_STEP=$WICRI_ROOT/Wicri/Musique/corpus/MozartV1/Data/France/Analysis
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   |wiki=    Wicri/Musique
   |area=    MozartV1
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   |type=    RBID
   |clé=     ISTEX:900E8450B99DEBF065F1AE2E0E01ECF2E5923394
   |texte=   In vitro influence of benfluorex and its main metabolites on rat liver microsomal membrane properties
}}

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